How Research and Development Pharmaceutical Chemist of the Multinational PFIZER aims to discover a new TARGET for the treatment of dyslipidemias with their respective leading compound. What would be your step-by-step strategy to achieve it?
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How Research and Development Pharmaceutical Chemist of the Multinational PFIZER
aims to discover a new TARGET for the treatment of
dyslipidemias with their respective leading compound.
What would be your step-by-step strategy to achieve it?
Step by step
Solved in 2 steps
- Suggest an appropriate reason for the observation : “On increasing temperature of the reacting system by 10 degrees, the rate of reaction almost doubles or even some times becomes five folds.”Cyanide ion (CN-) causes toxicity to humans, explain the reason of its toxicity to us. Suggest a method to remove its toxicity from the blood.Homopolysaccharide are found abundant in nature. Explain how this class ofpolysaccharide acts as primary component of plants and insects.
- Explain this quesiton in descrition format whether non-barbiturate drug classes are labeled at a lower or higher selection compared to barbiturates?. In what ways do the systematic developments of pesticidesand of pharmaceuticals resemble each other, and in whatways do they differ? Consider such aspects as “deceptor”molecules, which are mistaken by living organisms forother molecules; side effects; and the relative advantagesof a broad versus a narrow spectrum of activityMatch each inhibitor with its effect on Michaelis-Menten reactions. Group of answer choices Vmax and apparent Vmax are equal and the apparent Km is greater than Km. The apparent Vmax is less than Vmax and the apparent Km and Km are equal The apparent Vmax and the apparent Km are both lowered to the same degree. The apparent Vmax is less than Vmax and the apparent Km can be either greater than or less than Km.
- Understanding the Mechanisms of Reactions Related to Transketolase The mechanistic chemistry of the acetolactate synthase and phosphoketolase reactions (shown here) is similar to that of the transketolase reaction (Figure 22.30). Write suitable mechanisms for these reactions.In this diagram of an affinity label/suicide inhibitor at play, what is the difference between the reactive group and the specificity group?sodium nitrite (NaNO2) is used by emergency medical personnel as an antidote for cyanide poisoning (for this purpose, it must be administered immediately). Based on the discussion of cyanide poisoning, suggest a mechanism for the life-saving effect of sodium nitrite.
- The enzyme phospholipase A2 has an optimal pH of 5.5. If a biochemist wants to set up an in vitro assay to screen inhibitors of this enzyme, which buffer system would be BEST?Diazepam is converted in vivo to an active metabolite Oxazepam. Explain metabolic transfomation of diazepam to oxazepam. (Provide names of enzymes involved in this transformation. Drawings of structures ofintemediate metabolites is NOT required)One treatment for hyperuricemia is administration of xanthine oxidase inhibitors like allopurinol. Discuss the mechanism and show an illustration how this drug able to alleviate symptoms of hyperuricemia.