What is the relative inhibition of the kinase if the substrate concentration equals Ks And the concentration of the inhibitor equals K, ?
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Solved in 4 steps
- What happens when cAMP binds to the kinase?How can you decrease (or stop) the rate of binding for a noncompetitive inhibitor? Could you change the receptor allosteric sites to prevent noncompetitive binding?In Figure 4C, we see the inhibition of LRRK2 kinase activity by nanobody 1 (Nb1). Using the Lineweaver-Burke plot, estimate the Km of LRRK2 in the absence of Nb1. Show your work and provide your answer with the correct units.
- what are the consequences of covalent modulation and why kinases falls into two categories based on their substratesPay close attention to the information related to figure 3.14a and the structure of the PKA catalytic site in this figure. In a few well-written sentences, propose the following: A mutation that would result in PKA becoming a dead kinase*. A mutation that would result in PKA becoming a constitutively active** kinase.Explain how the addition of a phosphate group to certain amino acids of kinase D can result in the activation of D. Explain how the activation of the pathway shown in Figure 1 can lead to increased production of A.
