Human communities around the world that are isolated geographically or culturally serve as an important resource for studying human genetics. Why would research on recessive alleles benefit from these communities?

Human communities around the world that are isolated geographically or culturally serve as an important resource for studying human genetics. Why would research on recessive alleles benefit from these communities?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter6: Cytogenetics: Karyotypes And Chromosome Aberrations

Section: Chapter Questions

Problem 25QP: Albinism is caused by an autosomal recessive allele of a single gene. An albino child is born to...

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Albinism is caused by an autosomal recessive allele of a single gene. An albino child is born to phenotypically normal parents. However, the paternal grandfather is albino. Exhaustive analysis suggests that neither the mother nor her ancestors carry the allele for albinism. Suggest a mechanism to explain this situation.
Many genetic studies, particularly those of recessive traits, have focused on small, isolated human populations, such as those on islands. Suggest one or more advantages that isolated populations might have for the study of recessive traits.
The delta-32 mutation, a recessive gene, gives humans protection from HIV infection. The allele frequency in a town in Sweden is 20%. What percent of the population have two copies of the gene and are therefore immune to HIV? What percent of the population are less susceptible to the disease since they are heterozygous?
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Looking to the future, what changes to the frequency of the sickle-cell allele do you envision as most likely, and why? (In other words, do you envision it becoming more common or less common in human populations?) What factors (technology, climate change, etc) might be driving those changes?
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Heterozygote advantage is an interesting condition in those individuals who have one of each allele (dominant and recessive) have a higher survival rate than those individuals who are either homozygous dominant or homozygous recessive. Sickle-cell anemia is such a genetic disease associated with the recessive allele. Normal homozygous individuals (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to…
Albinism is a recessive trait in humans.A geneticist studies a series of families in which both parents have normal pigmentation and at least one child has albinism. The geneticist reasons that both parents in these families must be heterozygotes and that albinism should appear in 14 of their children. To his surprise, the geneticist finds that the frequency of albinism among the children of these families is significantly greater than 14. Can you think of an explanation for the higher-than-expected frequency of albinism among these families?
In humans, color blindness is a sex-linked recessive trait. A female who is a carrier (XBXb) for color blindness has children with a male with normal vision (XBY). Make a Punnett Square to help you answer the questions. What are the chances of their children being color blind? What are the chances of their children being ‘carriers’ for color blindness?
Just for fun, imagine that “shirt-striping” is a phenotypic character caused by a single gene. Construct a genetic explanation for the appearance of the family in the above photograph, consistent with their “shirt phenotypes.” Include in your answer the presumed allele combinations for “shirt-striping” in each family member.
Albinism is a recessive trait in humans . A geneticist studies a series of families in which both parents havenormal pigmentation and at least one child has albinism. The geneticist reasons that both parents in these families must be heterozygotes and that albinism should appear in 14 of their children. To his surprise, the geneticist finds that the frequency of albinism among the children of these families is significantly greater than 14. Can you think of an explanation for the higher-than-expected frequency of albinism among these families?