To determine whether radiation associated with the atomic bombings of Hiroshima and Nagasaki produced recessive germ-line mutations, scientists examined the sex ratio of the children of the survivors of the blasts. Can you explain why an increase in germ-line mutations might be expected to alter the sex ratio?

To determine whether radiation associated with the atomic bombings of Hiroshima and Nagasaki produced recessive germ-line mutations, scientists examined the sex ratio of the children of the survivors of the blasts. Can you explain why an increase in germ-line mutations might be expected to alter the sex ratio?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter15: Genomes And Genomics

Section: Chapter Questions

Problem 12QP: One unexpected result of the sequencing of the human genome was the finding that mutations in a...

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In humans, why is it that the mother determines whether her sons will get recessive sex-linked traits?
For sex-linked recessive traits, only females can be “carriers”, like how both Diana and Olivia are carriers for hemophilia. Why can’t males be carriers for these traits?
Why are lethal dominant genes much more rare than lethal recessive genes?
You find a person that has a new allele that is not found in DNA samples taken from skin cells of the mother or the father, suggesting that the mutation arose during the formation of the gametes that formed this person. Is it more likely that the mutation was present in the sperm or the egg that formed this person and why do you believe this is the case?”
A couple who are both heterozygous for an autosomal recessive mutation that is narrowly expressed and fully penetrant are planning on having three children. What is the probability that one their children will be normal (unaffected) and two children will have the recessive mutant phenotype? Show your work. Please answer this question using the Bayes’ Theorem
Why are recessive conditions more common than dominant ones? How could being a carrier of a recessive disease be beneficial?
Identical twins each carry the same genome, but over time, can develop different phenotypes. How can you explain this?
A rare recessive mutation causes rabbits that are normally white to be pink. If one in a hundred rabbits is pink, what is the frequency of the pink allele?
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Albinism is caused by an autosomal recessive allele of a single gene. An albino child is born to phenotypically normal parents. However, the paternal grandfather is albino. Exhaustive analysis suggests that neither the mother nor her ancestors carry the allele for albinism. Suggest a mechanism to explain this situation.
One unexpected result of the sequencing of the human genome was the finding that mutations in a single gene can be responsible for multiple distinct disorders. For example, mutations in the RET gene can cause two different types of multiple endocrine neoplasias, familial medullary thyroid carcinoma, and Hirschsprung disease. How do you think mutations in a single gene can have such diverse effects?