Identify the electrophilic centre that is attacked on the structure of parecoxib. For this question you will need to draw your answer on a separate sheet.

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions
Section21.SE: Something Extra
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Only give answer question num 1 please send me the question in 20 minutes it's very urgent plz
b) The enzyme catalysed conversion of parecoxib to valdecoxib in the liver occurs via attack of a
nucleophile on parecoxib.
i.
ii.
Identify the electrophilic centre that is attacked on the structure of parecoxib. For this question
you will need to draw your answer on a separate sheet.
Describe a possible way in which the electrophilic centre could be further activated within the
active site of the enzyme. Use resonance structures to illustrate your answer. For this question
you will need to draw your answer on a separate sheet.
Transcribed Image Text:b) The enzyme catalysed conversion of parecoxib to valdecoxib in the liver occurs via attack of a nucleophile on parecoxib. i. ii. Identify the electrophilic centre that is attacked on the structure of parecoxib. For this question you will need to draw your answer on a separate sheet. Describe a possible way in which the electrophilic centre could be further activated within the active site of the enzyme. Use resonance structures to illustrate your answer. For this question you will need to draw your answer on a separate sheet.
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