Identify the functional groups and predict the solubility of Ciprofloxacin and amoxicillin. Provide drawing and explanation. Table on solubility is given and examples Thank you!
Identify the functional groups and predict the solubility of Ciprofloxacin and amoxicillin. Provide drawing and explanation. Table on solubility is given and examples Thank you!
Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter21: Lipids
Section: Chapter Questions
Problem 21.13P: 21-13 Rank the following in order of increasing solubility in water (assuming that all are made with...
Related questions
Question
Identify the functional groups and predict the solubility of Ciprofloxacin and amoxicillin. Provide drawing and explanation.
Table on solubility is given and examples
Thank you!
Transcribed Image Text:Ciprofloxacin
F.
`OH
HN,
Amoxicillin
NH2 H
„CH3
CH3
НО
CO,H
Identify the functional groups present in each
drug and predict the drug solubility based on the
given table. (See attached examples)
Transcribed Image Text:pi Value
Fragment
C (aliphatic/cyclic)
+0.5
C (alkene-aliphatic/cyclic)
+0.33
(phenyl/benzene ring) C,H;-
+2.0
>/= to +0.5
Halogens (CI, F, Br)
+0.5
water insoluble
O,NO
+0.2
Intramolecular hydrogen bonding (IMHB)
+0.65
< +0.5
+0.5
water soluble
(carboxylic acid) O=C-O
-0.7
(amide) O=C-N
-0.7
O(hydroxyl, phenol, ether)
-1.0
N (amine-aliphatic/cyclic/aromatic)
-1.0
O,N (aliphatic)
-0.85
0,N (aromatic)
-0.28
Benzene 2
TOTAL: 3.95
WATER INSOLUBLE
C-aliphatic=0.5
N cyclic= -1
N
O=CN = -0.7
Benzene 2
HMHB= 0,65
C-aliphatic=0.5
Total: 5.28
Carbon
aliphatice
05
WATER INSOLUBLE
H,CO
Carbon
aliphatic=
0.5
Cyclic
alkene=0.33
H,CO
Carbon
alphatic=
OCH 05
OCN=-0.7
Carbon
OCH3 aliphatic=
6.5
Carbon
cyclic= 0.5
H.C
Benzene=2
Carbon
aliphatice
IMHB= 0.65
0.5
I ZI
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 3 steps with 1 images
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Recommended textbooks for you
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:
9781285869759
Author:
Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:
Cengage Learning
Introductory Chemistry: An Active Learning Approa…
Chemistry
ISBN:
9781305079250
Author:
Mark S. Cracolice, Ed Peters
Publisher:
Cengage Learning
Introductory Chemistry: A Foundation
Chemistry
ISBN:
9781337399425
Author:
Steven S. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:
9781285869759
Author:
Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:
Cengage Learning
Introductory Chemistry: An Active Learning Approa…
Chemistry
ISBN:
9781305079250
Author:
Mark S. Cracolice, Ed Peters
Publisher:
Cengage Learning
Introductory Chemistry: A Foundation
Chemistry
ISBN:
9781337399425
Author:
Steven S. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
General Chemistry - Standalone book (MindTap Cour…
Chemistry
ISBN:
9781305580343
Author:
Steven D. Gammon, Ebbing, Darrell Ebbing, Steven D., Darrell; Gammon, Darrell Ebbing; Steven D. Gammon, Darrell D.; Gammon, Ebbing; Steven D. Gammon; Darrell
Publisher:
Cengage Learning