Identify the partial sequence of events that occurs after the insulin binds to its receptor.   1. Phosphorylation of insulin receptor substrate (IRS-1) 2. Activation of the receptor tyrosine kinase activity 3. Activation of phosphodiesterase 4. Activation of phospholipase C 5. Phosphorylation of phosphatidylinositol 6. Activation of phosphatidylinositol-3 -kinase (P1-3 kinase) 7. Binding of Grb 2 8. Activation of a phosphatase 9. Dephosphorylation of pyruvate kinase 10. phosphorylation of pyruvate kinase

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter23: Endocrine System Drugs
Section: Chapter Questions
Problem 15CRQ
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Identify the partial sequence of events that occurs after the insulin binds to its receptor.

 

1. Phosphorylation of insulin receptor substrate (IRS-1)

2. Activation of the receptor tyrosine kinase activity

3. Activation of phosphodiesterase

4. Activation of phospholipase C

5. Phosphorylation of phosphatidylinositol

6. Activation of phosphatidylinositol-3 -kinase (P1-3 kinase)

7. Binding of Grb 2

8. Activation of a phosphatase

9. Dephosphorylation of pyruvate kinase

10. phosphorylation of pyruvate kinase

  1. 2-7-1-4-3-9
  2. 1-7-3-5-6-8
  3. 2-1-6-5-8-9
  4. 2-7-1-6-5-8-9
  5. 2-7-4-6-1-8-10
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