If one person with the trait of Huntington's disease (H h) has 2 children with a partner who does not have a trait for the disease what is the chance that both children won't have the disease? It Started with OneDo your genes matter to anyone besides you? Do they affect the rest of the population? Well, as it turns out,they might have more of an effect than you imagine.Huntington's disease (HD) is a rare, autosomal dominant neurodegenerative disease caused by a type ofmutation known as a triplet expansion. The triplet expansion occurs on a mutated HTT gene, where a triplet ofnucleotides (CAG) is repeated several times. The number of repeats also plays an important role in the age of onset ofthe disease; individuals who have 6-35 CAG repeats will be unaffected, while people with 40 or more CAG repeats areguaranteed to develop symptoms of the disease.HD is unique in that the symptoms and onset of the disease begin in adulthood, and usually appear around theage of 30-45; this means that many people who have the disease have already had kids and passed on the genetic traitbefore their symptoms even appeared. Symptoms of HD include: a loss of motor control, altered personality, and adecline in overall cognitive function. The disease is fatal and there are no current treatments to slow the progression ofthe disease.A small, rural fishing village in the state of Zulia, Venezuela has the highest concentration of people sufferingfrom Huntington's Disease in the world. In 1979, scientists caught wind of the alarming rates of HD in this area.Several research teams were sent to meet with the people in the village and take blood samples to examine their DNA.The data that was collected and continues to be collected from the people of this village has led to astoundingadvancements of our knowledge of the disease, which will hopefully one day lead to better treatments, prevention, andmaybe even a cure.Scientists were able to obtain over 4,000 blood samples for DNA analysis as well as an immense amount ofclinical data (i.e. family history, symptoms, etc.). Using this data they were able to determine the source of thedevastating genetic mutation, a single woman who helped found the village ten generations prior. Currently there areover 18,000 individuals living in this area of Venezuela who have Huntington's Disease. Examine Figures 1 and 2below then answer the corresponding questions..IIIIIVFig. 1 Pedigree depicting four generations of a Venezuelan Huntington's Disease family. Circles represent females and squaresrepresent males. A shaded symbol means they are affected with the disease. A slashed symbol means the individual has died.Fig. 2 Box plot representing the age of onset vs. the length of the tripletexpansion. The larger the boxes, the more data that fell within thatrange.404448525660Triplet Repeat Length (CAG)33Age of Onset

Name: If one person with the trait of Huntington's disease (H h) has 2 child
Uploaded: 2024-03-20T06:43:04.000Z
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Description: If one person with the trait of Huntington's disease (H h) has 2 children with a partner who does not have a trait for the disease what is the chance that both children won't have the disease? It Started with OneDo your genes matter to anyone besides

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INTRODUCTION
Huntington's disease
It is an inheritable disease in which nerve cells in the brain…