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- Based on the following seven-step synthetic scheme, answer the questions below. Indicate, in the schematic, the reagents you would use in each are available in the following inventory reagents from an FDA lab. NaCl, CH3OH, terbutanol, K, Na, K2SO4, THF, TsCl, NaOCH3, B2H6, H2O, H3PO4 85%, H2O2, H2O nanopura, PCC, K2Cr2O7, H2SO4, Mg, CH3Br, Cl2, NaOH, HBr 5%, HBr conc., fenolftaleína, dextrina, NaF, KMnO4, HCl 1%, CaCO3, C2H2, C6H6, H2, Pt, CCl4Using any necessary organic and inorganic reagents, show how you can carry out the chemical conversions shwon below. Please answer parts a, b, and c.The treatment of isoprene [CH2=C(CH3)CH=CH2] with one equivalent ofmCPBA forms A as the major product. A gives a molecular ion at 84 in itsmass spectrum, and peaks at 2850–3150 cm−1 in its IR spectrum. The 1HNMR spectrum of A is given below. What is the structure of A?
- One synthetic advantage of olefin metathesis is that the catalyst tolerates a variety of functional groups in the reactant. In a synthesis of the antiinfluenza drug Tamiflu (oseltamivir), ring-closing metathesis was used to prepare the highly functionalized cyclohexene derivative shown. What was the reactant?Propose a mechanism for the followingreaction.The treatment of isoprene [CH2 = C(CH3)CH = CH2] with one equivalent of mCPBA forms A as the major product. A gives a molecular ion at 84 in its mass spectrum, and peaks at 2850–3150 cm−1 in its IR spectrum. The 1H NMR spectrum of A is given below. What is the structure of A?
- Draw all steps in a proposed syntheticpathway to convert the starting material to the compounds shown below.You can use any inorganic reagent(s), sodium methoxide, sodium tert-butoxide, LDA,n-BuLi,m-CPBA, pyridine, PPh3, DCCand pyrrolidine. These conversions may take more than one step. Include all required reagents (solvents are not required), mechanisms are not required.a. Propose a synthetic pathway for cis-[NiCl2(CO)2] using trans-effect. b. Propose the methods to differentiate the isomers in between [RhCl2(H2O)4]Cl and [RhCl3(H2O)3].H2O.(10pts) Compound A, C10H16, was found to be optically active. On catalytic reduction over a palladium catalyst, 2 equivalents of hydrogen were absorbed, yielding compound B, CioH2o. On ozonolysis of A, two fragments were obtained. One fragment was identified as acetic acid (CHCOOH). The other fragment, compound C, was an optically active carboxylic acid, C8H14O2. Write reactions, and draw the correct structures for A-C, explain your answer in detail.
- Reaction of BrCH2CH2CH2CH2NH2 with NaH forms compound W, whichgives the IR and mass spectra shown in attachment. Propose a structure for Wand draw a stepwise mechanism that accounts for its formation.Over the past several decades, chemists have developed a number of synthetic methodologies for the synthesis of steroid hormones. One of these, developed by Lutz Tietze at the Institut für Organische Chemie der Georg-August-Universität, Göttingen, Germany, used a double Heck reaction to create ring B of the steroid nucleus. As shown in the following retrosynthetic analysis, a key intermediate in his synthesis is compound (1). Two Heck reaction disconnects of this intermediate give compounds (2) and (3). Compound (2) contains the aromatic ring that becomes ring A of estrone. Compound (3) contains the fused five- and six-membered rings that become rings C and D of estrone. Q.Propose structural formulas for compounds (2) and (3).Over the past several decades, chemists have developed a number of synthetic methodologies for the synthesis of steroid hormones. One of these, developed by Lutz Tietze at the Institut für Organische Chemie der Georg-August-Universität, Göttingen, Germany, used a double Heck reaction to create ring B of the steroid nucleus. As shown in the following retrosynthetic analysis, a key intermediate in his synthesis is compound (1). Two Heck reaction disconnects of this intermediate give compounds (2) and (3). Compound (2) contains the aromatic ring that becomes ring A of estrone. Compound (3) contains the fused five- and six-membered rings that become rings C and D of estrone. Q.Name the types of functional groups in estrone