HO Si Grubbs' catalyst CH2Cl2 NH 25°C NH

Pushing Electrons
4th Edition
ISBN:9781133951889
Author:Weeks, Daniel P.
Publisher:Weeks, Daniel P.
Chapter3: Mechanisms
Section: Chapter Questions
Problem 140EQ
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One synthetic advantage of olefin metathesis is that the catalyst tolerates a variety of functional groups in the reactant. In a synthesis of the antiinfluenza drug Tamiflu (oseltamivir), ring-closing metathesis was used to prepare the highly functionalized cyclohexene derivative shown. What was the reactant?

HO
Si
Grubbs'
catalyst
CH2Cl2
NH
25°C
NH
Transcribed Image Text:HO Si Grubbs' catalyst CH2Cl2 NH 25°C NH
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