This is a tyrosine kinase receptor.  a. Briefly describe the action of the receptor upon binding to the logand. b. There are several intracellular pathway possibilities for downstream responses. How might this receptor be able to selectively activate one particular pathway over another?

Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
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This is a tyrosine kinase receptor. 

a. Briefly describe the action of the receptor upon binding to the logand.

b. There are several intracellular pathway possibilities for downstream responses. How might this receptor be able to selectively activate one particular pathway over another?

VEGES
VEGFR-2
Plasma membrane
PIP3
PIP2
PIP2
DAG (PKC)
Ras
Y951)VRAP
-Y996
1054
Y1069 <PLOC
PI3K
IPs
SPK
0.
AKUPKB)
Rlac
Fal
FLC
038MAPK
Y1175.
(BAD
Y1214
Sck
Caspase
MEK
eNOS
ER
MAPKAPK2/3)
(FAK)
Src
Erk
Survival
(Paxilin
NO production
HSP27
CPLA
Focal adhesion
Actin
turn over
reorganization
PGI, production
Gene transcription
Nucleus
Permeability
Migration
Proliferation
TBS
4
Transcribed Image Text:VEGES VEGFR-2 Plasma membrane PIP3 PIP2 PIP2 DAG (PKC) Ras Y951)VRAP -Y996 1054 Y1069 <PLOC PI3K IPs SPK 0. AKUPKB) Rlac Fal FLC 038MAPK Y1175. (BAD Y1214 Sck Caspase MEK eNOS ER MAPKAPK2/3) (FAK) Src Erk Survival (Paxilin NO production HSP27 CPLA Focal adhesion Actin turn over reorganization PGI, production Gene transcription Nucleus Permeability Migration Proliferation TBS 4
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