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In genetic counseling, it is difficult to directly test if an individual has a recessive allele that is associated with an inherited disease. However, the individual many be tested for the marker that is located at a known distance from the disease gene. It is often possible to calculate the probability that the individual possesses the disease allele. presence of a particular DNA One recessive mutation in human chromosome 12 can cause a rare disease that leads to death within the first year. This is located approximately 20 cM from the centromere. A RFLP marker is identified to gene Father Mother Sister Sister2 Sister3 Mary RFLPS be as close as 8cM to this lethal The RFLP gene. Skb markers results from the presence or absence of a BamHI restriction presence of the BamHI site results in the production of 5 kb and 3 kb restriction fragment that can be visualized on an site. The enzyme Skb agarose gel. The absence of the Bam HI site results in an 8.0Kb fragment. Sistert Sister2 Sister3 Mary 3kdb Mary came froma family, which unfortunately carry this horrible gene. One of Mary sisters (sister1) passed away in her 6-month age. Mary is now~ about passing this recessive allele to her child. So she collected DNAS from all her families to do the RFLP test. The results are shown as above. Based on this information, please answer the following questions: old and planning a child. She is so concerned 25 year alb

In genetic counseling, it is difficult to directly test if an individual has a recessive allele that is associated with an inherited disease. However, the individual many be tested for the marker that is located at a known distance from the disease gene. It is often possible to calculate the probability that the individual possesses the disease allele. presence of a particular DNA One recessive mutation in human chromosome 12 can cause a rare disease that leads to death within the first year. This is located approximately 20 cM from the centromere. A RFLP marker is identified to gene Father Mother Sister Sister2 Sister3 Mary RFLPS be as close as 8cM to this lethal The RFLP gene. Skb markers results from the presence or absence of a BamHI restriction presence of the BamHI site results in the production of 5 kb and 3 kb restriction fragment that can be visualized on an site. The enzyme Skb agarose gel. The absence of the Bam HI site results in an 8.0Kb fragment. Sistert Sister2 Sister3 Mary 3kdb Mary came froma family, which unfortunately carry this horrible gene. One of Mary sisters (sister1) passed away in her 6-month age. Mary is now~ about passing this recessive allele to her child. So she collected DNAS from all her families to do the RFLP test. The results are shown as above. Based on this information, please answer the following questions: old and planning a child. She is so concerned 25 year alb

Human Heredity: Principles and Issues (MindTap Course List)
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter5: The Inheritance Of Complex Traits
Section: Chapter Questions
Problem 5QP: As it turned out, one of the tallest Potsdam Guards had an unquenchable attraction to short women....
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What is the probability of Sister 3 as a carrier of the death gene? 

In genetic counseling, it is difficult to directly test if an individual has a recessive allele that is associated with an inherited disease. However, the individual many be tested for the marker that is located at a known distance from the disease gene. It is often possible to calculate the probability that the individual possesses the disease allele. presence of a particular DNA One recessive mutation in human chromosome 12 can cause a rare disease that leads to death within the first year. This is located approximately 20 cM from the centromere. A RFLP marker is identified to gene Father Mother Sister Sister2 Sister3 Mary RFLPS be as close as 8cM to this lethal The RFLP gene. Skb markers results from the presence or absence of a BamHI restriction presence of the BamHI site results in the production of 5 kb and 3 kb restriction fragment that can be visualized on an site. The enzyme Skb agarose gel. The absence of the Bam HI site results in an 8.0Kb fragment. Sistert Sister2 Sister3 Mary 3kdb Mary came froma family, which unfortunately carry this horrible gene. One of Mary sisters (sister1) passed away in her 6-month age. Mary is now~ about passing this recessive allele to her child. So she collected DNAS from all her families to do the RFLP test. The results are shown as above. Based on this information, please answer the following questions: old and planning a child. She is so concerned 25 year alb
Transcribed Image Text:In genetic counseling, it is difficult to directly test if an individual has a recessive allele that is associated with an inherited disease. However, the individual many be tested for the marker that is located at a known distance from the disease gene. It is often possible to calculate the probability that the individual possesses the disease allele. presence of a particular DNA One recessive mutation in human chromosome 12 can cause a rare disease that leads to death within the first year. This is located approximately 20 cM from the centromere. A RFLP marker is identified to gene Father Mother Sister Sister2 Sister3 Mary RFLPS be as close as 8cM to this lethal The RFLP gene. Skb markers results from the presence or absence of a BamHI restriction presence of the BamHI site results in the production of 5 kb and 3 kb restriction fragment that can be visualized on an site. The enzyme Skb agarose gel. The absence of the Bam HI site results in an 8.0Kb fragment. Sistert Sister2 Sister3 Mary 3kdb Mary came froma family, which unfortunately carry this horrible gene. One of Mary sisters (sister1) passed away in her 6-month age. Mary is now~ about passing this recessive allele to her child. So she collected DNAS from all her families to do the RFLP test. The results are shown as above. Based on this information, please answer the following questions: old and planning a child. She is so concerned 25 year alb
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