In a family-based genetic study for a mental disorder called marijuana dependence, a total of 50 families, each with a pair of siblings, were recruited. The result showed that 11 families have the 1st siblings with marijuana dependence and the 2nd siblings without the disorder, while another 9 families are opposite (i.e. the 1st siblings without the disorder but the 2nd siblings with the disorder). In contrast, 13 families have both siblings exhibiting the disorder and another 17 families have both siblings without the disorder. What kind of heritability can you calculate using this family study and what is the heritability value for marijuana dependence? OA Broad-sense heritability, approximately 38% O B. Narrow-sense heritability, approximately 38% OC Narrow-sense heritability, approximately 76% O D. Broad-sense heritability, approximately 76%
Q: A geneticist examines an ear of corn in which most kernels are yellow, but he finds a few kernels…
A: The anthocyanin pigment produced by corn is responsible for its peculiar purple colour. This happens…
Q: What is the mathematical expression of the genetic equilibrium for genes with two alleles? Is this…
A: The Hardy-Weinberg equilibrium is a standard expressing that the hereditary variety in a populace…
Q: What does the expression linear octad analysis mean?
A: Fungi are eukaryotic heterotrops that grow and form thread like structures called hyphae to form a…
Q: What is a genetic familytree?
A: Genetics is the study of genes, variations, and mechanisms of heredity in organisms. Parents inherit…
Q: Assume that the count of F2 phenotypes you got is as follows: Phenotype F2 count b P t 90 b P T 5 b…
A: Genetic mapping is used to identify the linear order of genes along with the relative distance…
Q: Normal wife Affected husband As a genetic counsellor you are presented with a married couple where…
A: As the male is affected and women is normal. They have a carrier daughter, normal son, normal…
Q: For decades scientists have been perplexed by different circumstances surrounding families with…
A: Genetics is the branch of biology which deals with genes, heredity, and genome in the organism.…
Q: In a study of a muscle disorder, several affected families exhibited vision problems, muscle…
A: Genes in nuclear content express most of the characters, while some of the characters are associated…
Q: Susan's grandfather was deaf, and passed down a hereditary form of deafness within Susan's family as…
A: Diseases are set to be autosomal dominant is only one set of chromosome is required for the disease…
Q: What is a gene family? How are gene families produced over time?With regard to gene function, what…
A: Gene is known to be a hereditary unit. They are composed of DNA or deoxyribonucleic acid and some of…
Q: What is the probability that their firstborn child will be inartistic, immoral and greedy? What is…
A:
Q: Marfan syndrome is a disease caused by a rare dominant allele of the fibrillin-1 gene. Fibrillin-1…
A: Marfan syndrome refers to the genetic disorder related to connective tissue characterized by tall…
Q: a certain family with both parents affected with Heberdon’s nodes, a single gene trait characterized…
A: There are many four different modes of inheritance autosomal dominant, autosomal recessive, X linked…
Q: Many genetic disorders exhibit locus heterogeneity. Define andgive two examples of locus…
A: Locus heterogeneity is a phenomenon in which a particular disease is caused by mutations in…
Q: What is the most likely order of the linked genes R, S, and T if the distance between R and S is 22…
A: The above scenario based on linkage and maping.
Q: Sandhoff disease is due to a mutation in a gene that encodes a proteincalled hexosaminidase B. This…
A: Step 1 Genetic disorders are defects that are caused by a genetic mechanism. The genetic character…
Q: What is the most convenient way of understanding a testcross problem in genetics?
A: In genetics, test cross is the breeding of an individual with a phenotypically recessive individual,…
Q: You have the following DNA coding sequence of a wild-type allele: 5’-ATG TTC CAG CTA GAT GAT ATG CTG…
A: This question has more than one to be answered. This is against the rules of bartleby.com and hence…
Q: A recessive maternal effect mutant in zebrafish, called ichabod, results in embryos lacking heads…
A: Maternal effect in zebrafish is a situation where the phenotype of an organism is determined not…
Q: Tay-Sachs disease is caused by loss of function mutation in a gene on chromosome 15 that codes for…
A: Tay-Sachs disease is a rare inherited disorder and this is due to mutation occurring in HEX A gene…
Q: A group of geneticists are interested in identifying genes that may play a role in susceptibility to…
A: LOD is the term used in pedigree analysis. Pedigree analysis is the way in which a single inherited…
Q: *22. Dent disease is a rare disorder of the kidney in which reabsorption of filtered solutes is…
A: DNA is the genetic material in most living organisms. DNA contains inheritable segments that are…
Q: Phenylketonuria (PKU) is an inherited disease caused by a recessive allele. Individuals with PKU…
A: Thank you for the question INTRODUCTION :- Phenylketonuria is a genetic disorder is which the body…
Q: In a particular country in sub-Saharan Africa, a medical study revealed that 0.075% of the country's…
A: Hardy Weinberg equilibrium states that the relative frequencies of various kinds of genes in a large…
Q: Why is knowing the genetic basis of a trait such as blond hair important? Why would scientists go to…
A: Genetics is the study of genes, their interactions, and the effect of environment on genes. Broadly…
Q: One particularly useful feature of the Hardy-Weinberg equation is that it allows us to estimate the…
A: Hardy-Weinberg equilibrium states that, in a population allele and genotypic frequencies will remain…
Q: The DNA of every individual in the pedigree shown below has been sequenced at the causative locus.…
A: Inheritance or heredity is passing on one trait from the parents to the progeny by either asexual or…
Q: What are the mainconventional symbols andsigns used in genetic familytrees?
A: The basic principles of inheritance as applicable to all other living organisms are equally…
Q: mammals, albinism is caused by an autosomal allele that interferes with skin pigment. Early one…
A: Albinism is an autosomal recessive trait. Normal = AA, Aa Albino = aa
Q: Tay–Sachs disease is caused by loss-of-function mutations ina gene on chromosome 15 that encodes a…
A: Tay–Sachs disease can be defined as a hereditary condition that causes nerve cells present in the…
Q: Compare and contrast the molecular and phenotypic features of Prader-Willi and Angelman syndromes.
A: Prader villi and angle man syndrome are imprinting disorders. Both are related to abnormalities in…
Q: A made-up genetic phenotype in humans results in some people having both brown and blond body hair.…
A: In an individual, the phenotypic traits are determined by inherited genes from his/her parents.…
Q: what is the general definition of gene drive and how does it differ from a gene expression pattern…
A: Gene drives can arise through a variety of mechanisms. They have been proposed to provide an…
Q: Draw each of the following base pairs: A-T, G-C, and U-
A: Adenine, guanine, cytosine and thymine are the nitrogenous bases which are present in DNA and in RNA…
Q: A woman diagnosed with early-onset Alzheimer's due to a mutation of the APP genehas children with a…
A: Azheimer's disease (AD) is a neurodegenerative disorder characterized by progressive dementia and…
Q: In a diploid organism of 2n=10, assume that you can label all the centromeres derived from its…
A: Meiosis creates gametes such as egg and sperm cells. During meiosis, the genetic information is…
Q: How can epigenetics result in phenotypic ratios that differ from ratios predicted by simple…
A: In epigenetics, changes are reversible and do not change DNA sequencebut they can change how the…
Q: If the two genes are 30 mu apart and the plant is (AB/ab), what proportion of gametes from a single…
A: Recombination frequency in a cross over; generally measured via map units(distance between two…
Q: Person A and person B are both worried they are going to develop a neurodegenerative disease.…
A: Parkinson's disease is the neurodegenerative disease which is caused by the imbalance in…
Q: What are geneticmutations?
A: A gene is a sequence of nucleotides in genome that codes for a functioning molecule. There is…
Q: What is the most likely order of the linked genes R, S, and T if the distance between R and S is 22…
A: A gene is the basic physical and the functional unit of heredity. Genes are made up of the DNA. Some…
Q: What does a recombination frequency of 50 indicate?
A: Recombination frequency is the proportion of the number of recombinant offsprings resulted in a…
Q: epigenetic deviate from Mendelian patterns?
A: Epigenetic epigenetics involves the study and explanation of how environmental factors affect the…
Q: What genetic model of an organism is the most ideal? And why is it an ideal model in genetics?
A: Genetics is a scientific study that deals with heredity and variation of the inherited…
Q: what is the significance of mutations in the emergence of new genetic properties (alleles) that may…
A: Mutations emerge when there is some sudden alteration in the individual’s genetic material or DNA…
Q: Females of wild-type Strain A and males of mutant Strain B, as well as females of mutant Strain B…
A: Reciprocal crosses are done by taking both genotype (once a male and once a female).
Q: 5'-TTATTTGAGGAGAATGATGTAAACCTGACCCAC-3’ wild-type allele 3'-ААТАААСТССТСТТАСТАСАТТTGGAСTGGGTG-5'…
A: a. What type of mutation is allele B: insertion, deletion, substitution, or inversion? Ans-…
Q: In rabbits, the gene for fur color is multiallelic. Agouti (C) is dominant to chinchilla (Cch),…
A: Term Phenotype refers to the observable characteristics or physical properties which can be observed…
Step by step
Solved in 2 steps
- Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?The pedigree below shows that inheritance of a disease that is caused by a late onset, dominant, autosomal mutation that is rare, but only 50% penetrant. The gene that is mutated in the disease is linked at a distance of 10 cm to a microsatellite marker that has alleles numbered 1, 2, and 3. The marker alleles detected in each individual are indicated below. What is the probability that individual A will develop the disease? Explain using an illustration of this occurs.A geneticist examines an ear of corn in which most kernels are yellow, but he finds a few kernels with purple spots, as shown here. Give a possible explanation for the appearance of the purple spots in these otherwise yellow kernels, accounting for the different sizes of the spots.
- Many genetic disorders exhibit locus heterogeneity. Define andgive two examples of locus heterogeneity. How does locus heterogeneityconfound a pedigree analysis?Why does epigenetic deviate from Mendelian patterns?There are two genetic disorders that result from mutation in imprinted genes: Prader-Willi syndrome and Angelman syndrome. Prader-Willi syndrome results from deletion of region 15q11-q13, which in healthy individuals is a region imprinted such that only the paternal copy is expressed. In the pedigree above, individual I-1 is heterozygous for a deletion of region 15q11-q13 and does not have Prader-Willi syndrome. Individuals I-2 and II-1 are both homozygous wild type for the region. Which individuals in the pedigree might have Prader-Willi syndrome? (Who could potentially have the syndrome, based on what alleles it is possible for them to inherit and express?) Question 9 options: Only II-2 could have Prader-Willi syndrome III-1 could have Prader-Willi syndrome in the presented pedigree; II-2 could only have had it if she were male Both II-2 and III-1 could have Prader-Willi syndrome II-2 could have…
- Tay-Sachs disease is a rare human disease in which toxic substances accumulate in nerve cells. The recessive allele responsible for the disease is inherited in a simple Mendelian manner. For unknown reasons, the allele is more common in populations of Ashkenazi Jews of eastern Europe. A woman is planning to marry her first cousin, but the couple discovers that their shared grandfather’s sister died in infancy of Tay-Sachs disease.a. Draw the relevant parts of the pedigree, and show all the genotypes as completely as possible. b. What is the probability that the cousins’ first child will have Tay-Sachs disease, assuming that all people who marry into the family are homozygous normal?For decades scientists have been perplexed by different circumstances surrounding families with rare, early-onset auditory neuropathy (deafness). In some families, parents and grandparents of the proband have normal hearing, while in other families, a number of affected (deaf) family members are scattered throughout the pedigree, appearing in every generation. Assuming a genetic cause for each case, offer a reasonable explanation for the genetic origin of such deafness in the two types of families.Which members of the pedigree could have been carriers, and which might have been the source of the mutation?
- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?