In order to manufacture insulin for patients with diabetes, scientists create recombinant DNA by inserting a human insulin gene into bacterial DNA and have the bacteria produce human insulin. Based on what you have learned in this unit about gene expression, what must the scientists do to the DNA sequence of the human insulin gene BEFORE inserting it into the bacteria, in order to have them produce the same insulin sequence that humans would produce? Explain

In order to manufacture insulin for patients with diabetes, scientists create recombinant DNA by inserting a human insulin gene into bacterial DNA and have the bacteria produce human insulin. Based on what you have learned in this unit about gene expression, what must the scientists do to the DNA sequence of the human insulin gene BEFORE inserting it into the bacteria, in order to have them produce the same insulin sequence that humans would produce? Explain

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Description: In order to manufacture insulin for patients with diabetes, scientists create recombinant DNA by inserting a human insulin gene into bacterial DNA and have the bacteria produce human insulin. Based on what you have learned in this unit about gene ex

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter15: Genomes And Genomics

Section: Chapter Questions

Problem 12QP: One unexpected result of the sequencing of the human genome was the finding that mutations in a...

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Which of the following scenario will result in greater consequences in terms of gene expression? insertion or deletion of one nucleotide insertion or deletion of three nucleotides Explain why.
Imagine you are a cell and you need to activate ("turn on") a gene as quickly as possible. What type of gene expression regulation would you use to achieve this?
The sequencing of entire genomes has made it possible to examine the level of gene expression in a particular cell or tissue by using oligonucleotide probes to assess the mRNA expression level from a particular gene. This is done most effectively through the use of what experimental technique?
Which of the following gene expression regulatory mechanisms saves the most energy but takes the longest to fully express the genes once signaled? a. transcriptional regulation b. post-transcriptional regulation c. post-translational regulation d. translational regulation
At the molecular level, how do you think a gain-of-function mutation in a developmental gene might cause it to be expressed in the wrong place or at the wrong time? Explain what type of DNA sequence would be altered.
a hormone receptor gene is deleted from the genome of a cell.in the absence of the hormone,what would you except about the expression of a gene that is activated by the hormone signiling?what would you expect to happen to the gene expression if the same cell is now treated with hormone?
You are curious to identify the region of the gene X sequence that serves as an enhancer for gene expression. Design an experiment to investigate this issue.
If you knew the mRNA sequence for the human insulin gene could you know what size cDNA fragment you would find on your DNA gel when you ran it against a size standard (a “molecular ruler”)? Would you continue with your insulin cloning experiment, if the DNA from your PCR was very different in size from that predicted by the insulin mRNA? Why or why not?
You are studying a new gene that is expressed within the adipose tissue of humans during the development of diabetes. Specifically, you want to learn why gene expression levels are very high in those people who develop diabetes. What DNA sequence would you concentrate on? Group of answer choices A specific response elements B the TATA box C enhancer sequences D promoter proximal elements E metal response elements
How might a point mutation in DNA affect the phenotype. How the genome is expressed in the organism? (Please explain this at the molecular level).
One unexpected result of the sequencing of the human genome was the finding that mutations in a single gene can be responsible for multiple distinct disorders. For example, mutations in the RET gene can cause two different types of multiple endocrine neoplasias, familial medullary thyroid carcinoma, and Hirschsprung disease. How do you think mutations in a single gene can have such diverse effects?
A biology professor at a prestigious university stated to his introductory class that "Today, a basic understanding of DNA and genetics is as important as a basic understanding of computers and the internet."Based upon what you have learned about DNA and gene expression in this module, how could you make a case to support this statement?