In recent years, the country of Zambia in Africa has had increasing cases of malaria. If 8 % of the population is born with a severe form of sickle-cell anemia (ss), what percentage of the population will be more resistant to malaria because they are heterozygous (Ss) for the sickle-cell gene, under the Hardy-Weinberg assumption

In recent years, the country of Zambia in Africa has had increasing cases of malaria. If 8 % of the population is born with a severe form of sickle-cell anemia (ss), what percentage of the population will be more resistant to malaria because they are heterozygous (Ss) for the sickle-cell gene, under the Hardy-Weinberg assumption

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter19: Population Genetics And Human Evolution

Section: Chapter Questions

Problem 2CS: If allele frequencies in the hemoglobin gene are influenced by sickle cell anemia on the one hand...

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If, within specific regional populations over two thousand years ago, sickle-cell anemia killed those individuals born with it before they could reproduce to pass it on to offspring, how did it persist in these populations? Group of answer choices A-Because of late-onset of the disease. B-Because it is cause by a virus and it spreads faster than people died. C-Because of the basic principles of mendelian inheritance that result in some heterozygote "carrier" combinations. D-Because malaria made it possible to survive sickle cell anemia since the parasite would carry oxygen on the blood cells with the mutated hemoglobin. E-It does not persist. Natural selection removes the allele because people die from both malaria and sickle-cell anemia.
If allele frequencies in the hemoglobin gene are influenced by sickle cell anemia on the one hand and by resistance to malaria on the other hand, what factors may cause a change in these allele frequencies over time?
What would happen to the frequency of heterozygous carriers of sickle-cell anemia (with AS genotype) if mosquitoes were completely wiped out in a large region?
Why does sickle-cell anaemia persist in the human population when it is believed that the harmful alleles get eliminated from the population after a certain time?
Explain the High frequency of the sickle-cell allele HbβS in regions of Africa where malaria is prevalent?
Do you think the allele for sickle cell anemia would be common in regions where malaria did not exist? Explain why or why not.
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In a region of Africa, where malaria is prevalent, 40% of the population are found to have sickle-cell anemia. The disease is caused by an abnormal hemoglobin that is found in both homozygotes (S2S2) and heterozygotes (S1S2). Many homozygotes (S2S2) suffer from anemia and often die. Heterozygotes (S1S2) incur a much less debilitating malady called "sickling trait". Approximately 3% of the people with abnormal hemoglobin are homozygotes (1.2\% of the entire population). The fitness of the S2S2 homozygotes is only 1/4 that of the heterozygotes. Where malaria is prevalent, heterozygotes exhibit overdominance with respect to fitness. How would you calculate relative fitness of the S1S1 homozygotes if you're assuming the population is at an equilibrium frequency for S2?
what fraction of the offspring of two parents with sickle trait would you expect to have sickle cell anemia? Explain how you arrived at this answer. Also include a punnet square
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It has been hypothesized that people who are heterozygous for the allele that causes the deadly genetic condition cystic fibrosis (which, among other symptoms, reduces fertility) are more resistant to the deadly disease tuberculosis. Question - if the cystic fibrosis allel protects against tuberculosis the same what the sickle cell allele protects against malaria, then which of the following should be true in comparison between regions with or with out TB. -cystic fibrosis deaths should be more common in regions with tb - CYSTIic fibrosis deaths should be less common in regions with tb - CYSTIic fibrosis deaths should be equally common in regions with tb -Regional differences in the cystic fibrosis death rate should be purly random and upredictable.