In the crusade to create a vaccine for Poliomyelitis, Jonas Salk and Albert Sabin created two separate vaccines that proved to be successful in preventing Polio onset.The Salk vaccine, which is given by standard injection, contained virus particles inactivated by an organic solvent. This method has the advantage of inactivating each of the three Polio strains withno bias,Albert Sabin's vaccine, given by oral inoculation via sugar water, contained live virus particles that had been genetically attenuated. With this method, each of the three Polio strains acquiredseparate mutations that made them unable to infect the human host cells. Strain 2 in particular contained one single nucleotide polymorphism in the internal ribosomal entry site (IRES) thatprevented successful viral replication.The organic solvent used to inactivate the Poliovirus in the Salk vaccine significantly alters the viral capsid. For the purposes of this question, let us assume that the capsid proteins are boundtogether by multiple di-sulfide bonds. Given this information, which of the solvents listed below would be most effective in disrupting the Poliovirus capsid?O MethanolO EthanolO Dimethyl sulfoxide (DMSO)O 2-mercaptoethanol

Solvents is the substance in which solute is dissolved thus forming a solution. Usually a solvent is…

Answered: In the crusade to create a vaccine for…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

See similar textbooks

Similar questions

A COVID-19 test, which produce result in 10 minutes, has the following test characteristics. The test has a 95% sensitivity and a 95% specificity. The State of Massachusetts is in dilemma whether to test symptomatic individuals or the entire residents to decrease the spread of infection as depicted in the following two scenarios. Scenario A. The State of Massachusetts wants to administer the test on 40,000 individuals who will develop cough, fever and shortness of breath in the next 10 days to identify COVID-19 infected individuals and institute public health measures. The estimated prevalence of COVID-19 in this population is 750 per 1,000 population using a gold-standard test. Scenario B. The State of Massachusetts wants to administer the test to its entire COVID-19 uninfected population (6,750,000). The estimated prevalence of COVID-19 in this population is 5 per 1,000 population using a gold-standard test. Please help the State of Massachusetts by responding to the…
A patient admitted to the hospital for fever and coughing is diagnosed with an active tuberculosis infection, and is treated with an antibiotic named rifampin. The antibiotics seemed successful, and his subsequent tests for tuberculosis came back negative. However, he was re-admitted to the hospital two months later with similar symptoms, was treated with rifampin again, and died of respiratory failure shortly thereafter. It was concluded that he had been infected with an antibiotic-resistant strain of M. tuberculosis. Does this situation meet the criteria for evolution by natural selection? Briefly explain how each of Darwin’s postulates is met/not met: a. Individuals in a population vary in traits. b. Traits are heritable. c. More offspring are produced than can survive, and only some individuals survive and reproduce. d. Individuals with certain heritable traits are more likely to survive and reproduce than others.
Some older vaccines used a weakened strain of the pathogenic virus in the injection in the hope that the weakened virus would induce an immune response without causing disease. The virus vectors used in genetic engineering have all the harmful virus genes cut out and replaced with the foreign gene, such as one that makes a protein that is absent in the human patient. Which type of viral vaccine would you prefer to take as the safest option? Why? Some Covid 19 vaccines in development use the adenovirus, a common vector used in gene therapies, to inject the mRNa for the spike protein into human muscle cells. Why might vaccines using a virus vector be more likely to need only refrigeration and not deep-cold storage, given what you know about viruses?
To test what is the optimal vaccine for disease X, we vaccinated 4 people at different concentrations of killed pathogen. a. Is it an active or passive vaccine? Explain your answer. b. Which of the subjects was vaccinated with a high concentration of killed pathogen? Which of the people get a very low concentration of Killed pathogen? Explain your answer. c. If an epidemic breaks out 100 days after the first vaccination, which of the people in the figure should be vaccinated so as not to Will get sick? Which vaccine will you choose? d. Describe in words and illustration what the response of the vaccine will look like in person 1 and in person 3 following another vaccine 70 Days after the first vaccination. What feature of the immune system is expressed here? e. . Is it the innate or acquired immune system? Explain your answer. f. If an epidemic of another disease breaks out, are these people vaccinated against it? Explain your answer.What feature of the immune system is expressed here?
Before development of a vaccine against this microbe, thedisease it caused accounted for two-thirds of bacterial meningi-tis cases during the first year of life but is still the number oneleading cause of mental retardation in patients who survive seri-ous disease due to permanent central nervous system disorders.What is the microorganism?(a) Haemophilus influenzae type B(b) Haemophilus influenzae type A(c) Neisseria meningitidis(d) Streptococcus pneumoniae(e) Listeria monocytogenes
The increased incidence of covid-19 cases is due to the delta variant which has been found primarily to be airborne. Viruses and other microorganisms are considered to be constituents of particulate air pollutants. The DENR-EMB requires engineering tools and techniques that would significantly reduce the emission of pollutants into the atmosphere. Which of these tools and techniques would be the most appropriate for use in reducing particulate pollutants carrying covid-19 viruses? Why?
In a recent influenza epidemic, physicians were utilizing a rapid diagnostic test to determine which patients were infected with influenza type A, type B, or not infected with influenza virus. Such a test was not available in the massive 1918 outbreak that killed millions of people around the globe. How might the availability of such a test have impacted that outbreak, and why?
A government official interested in determining the number of infants affected with the human immunodeficiency virus (HIV) has approached your hospital to participate in a statewide funded study. The protocol will include the testing of all newborns for HIV, but the mothers will not be told that the test is being done, nor will they be told the results? Using the basic ethical principles (available in the resources file), defend or refute the practice. How will the findings of the proposed study be affected if the protocol is carried out?
Type S Streptococcus pneumoniae bacterium is lethal and will kill its host. If heat inactivated the S strain dies and becomes nonlethal. Type R Streptococcus pneumoniae is a nonvirulent strain of bacteria. What would occur if one were to inject both the R strain and heat-killed S strains into a host organism such as the mouse? The R strain would be transformed into the virulent S strain and kill the host. Neither the S nor the R strain would change. The R strain would be transformed into the virulent S strain and not affect the host. The S strain would be transformed into the nonvirulent R strain and not affect the host The S strain would be transformed into the nonvirulent R strain and kill the host.
What actions described in the video do you think are similar to the COVID-19 threat today and why? What efforts by the government or other officials actually made the 1918 pandemic worse? Are any of these same actions occurring today? What is most shocking to you about the events described in the video about the 1918 pandemic? Are any of those shocking events now occurring in a similar way in response to COVID-19?
Answer the following and inlcude the references SARS-CoV-2, the virus that causes CoVid-19, belongs to the Coronaviridae family. Viruses under this family have a genome made of single-stranded positive-sense RNA. Is this similar to the viral genome of HIV? If so, do you think that – in theory – they would have similar replication cycles? Do you think that ART combinations/options might help in suppressing the viral replication of SARS-CoV-2? Expound.
You have been hired by a major pharmaceutical company to develop a new vaccine toprevent COVID-19 infection and spread.a. What is a virus? Describe the viral life cycle. (3 marks)b. Describe the difference between an antiviral drug and a vaccine. (1 mark)c. What are three qualities you would prioritize when developing this new vaccine forCOVID-19 that you would want in the end-product? (6 marks) Note: Qualities should be overarching characteristics of the developed drug, not specifics regarding various molecular mechanisms of action

SEE MORE QUESTIONS

Recommended textbooks for you

Biochemistry

ISBN:

9781319114671

Author:

Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:

W. H. Freeman

Lehninger Principles of Biochemistry

Biochemistry

ISBN:

9781464126116

Author:

David L. Nelson, Michael M. Cox

Publisher:

W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul…

Biochemistry

ISBN:

9781118918401

Author:

Donald Voet, Judith G. Voet, Charlotte W. Pratt

Publisher:

WILEY

Biochemistry

ISBN:

9781319114671

Author:

Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:

W. H. Freeman

Lehninger Principles of Biochemistry

Biochemistry

ISBN:

9781464126116

Author:

David L. Nelson, Michael M. Cox

Publisher:

W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul…

Biochemistry

ISBN:

9781118918401

Author:

Donald Voet, Judith G. Voet, Charlotte W. Pratt

Publisher:

WILEY

Biochemistry

ISBN:

9781305961135

Author:

Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal

Publisher:

Cengage Learning

Biochemistry

ISBN:

9781305577206

Author:

Reginald H. Garrett, Charles M. Grisham

Publisher:

Cengage Learning

Fundamentals of General, Organic, and Biological …

Biochemistry

ISBN:

9780134015187

Author:

John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson

Publisher:

PEARSON

SEE MORE TEXTBOOKS