In the Kaplan-Meier graph, why are the estimated curves for both groups (Treatment and Placebo) at 1 (100%) when time since randomization (the follow-up period) is 0 months?

Nutrition Through The Life Cycle
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ISBN:9781337919333
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Chapter18: Nutrition And Older Adults
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10. An article in JAMA: Psychiatry presents the results of a randomized controlled trial of Paliperidone Palmitate (Treatment)
compared to Placebo for preventing relapse in patients diagnosed with schizophrenia. Patients were followed for up to
500 days after randomization, until relapse or censoring.
The risk of relapse in the follow-up period is summarized by randomization group in the following Kaplan-Meier curve.
The vertical dashes on each curve represent censoring times.
Final analysis
1.0-
0.8-
0.6-
0.4-
3-mo formulation of paliperidone palmitate (n-160)
Placebo (n- 145)
++ Censored
0.2-
P<001
0-
Day 395
100
200
300
400
500
Time Since Randomization, d
Time, d
30
60
90
120
150
180
210
240
270
300
330
360
390
420
450
In the Kaplan-Meier graph, why are the estimated curves for both groups (Treatment and Placebo) at 1 (100%)
when time since randomization (the follow-up period) is 0 months?
Estimated Proportion of Patients Without Relapse
Transcribed Image Text:10. An article in JAMA: Psychiatry presents the results of a randomized controlled trial of Paliperidone Palmitate (Treatment) compared to Placebo for preventing relapse in patients diagnosed with schizophrenia. Patients were followed for up to 500 days after randomization, until relapse or censoring. The risk of relapse in the follow-up period is summarized by randomization group in the following Kaplan-Meier curve. The vertical dashes on each curve represent censoring times. Final analysis 1.0- 0.8- 0.6- 0.4- 3-mo formulation of paliperidone palmitate (n-160) Placebo (n- 145) ++ Censored 0.2- P<001 0- Day 395 100 200 300 400 500 Time Since Randomization, d Time, d 30 60 90 120 150 180 210 240 270 300 330 360 390 420 450 In the Kaplan-Meier graph, why are the estimated curves for both groups (Treatment and Placebo) at 1 (100%) when time since randomization (the follow-up period) is 0 months? Estimated Proportion of Patients Without Relapse
Because the follow-up period is less than 2 years.
Because 100% of the subjects relapsed at 0 months of follow-up.
Because 100% of the subjects were censored by the end of the study.
Because all subjects followed in this study were event free (had not yet relapsed) at the beginning of the study
Transcribed Image Text:Because the follow-up period is less than 2 years. Because 100% of the subjects relapsed at 0 months of follow-up. Because 100% of the subjects were censored by the end of the study. Because all subjects followed in this study were event free (had not yet relapsed) at the beginning of the study
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