John and Maggie are expecting a child. John's great-grandmother (mother's lineage) and Maggie's brother have a rare autosomal recessive condition. (A pedigree has been provided.) If they are dizygotic twins (fraternal or non-identical twins), what is the chance that at least one of them will be affected? Rare Z0 AR disorder preanancy of unknown gender. John Maggie
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- Martin and Sue are contemplating having children, but Martin’s brother has an autosomal recessive disease and Sue’s great-grandmother also had the same disease. Sue has a sister who has three normal, healthy children. What is the probability that Martin and Sue’s first child will have the autosomal recessive disease? HINT draws out pedigree charts and punnett squares for Martin and Sue.Frank and Susan both have freckles but they're firstborn son Lawrence does not demonstrate the characteristics. What are the most likely genotype of Frank Susan and Lawrence?A couple who are about to get married learn from studying their family histories that, in both their families, theirunaffected grandparents had siblings with cystic fibrosis(a rare autosomal recessive disease).a. If the couple marries and has a child, what is theprobability that the child will have cystic fibrosis?b. If they have four children, what is the chance that thechildren will have the precise Mendelian ratio of 3:1 fornormal:cystic fibrosis?c. If their first child has cystic fibrosis, what is theprobability that their next three children will be normal?
- A couple has 4 children, 2 sons and 2 daughter. The mother and the daughter is known to have a genetic disorder. Draw a pedigree that describes the familyDescriby cystic fibrosis as it applies to autosomal recessive inheritanceOn the left side of this figure, explain why the offspringdoes not have Prader-Willi syndrome but does have Angelman syndrome
- Parents Genotype : Bb/bb – Eye Color - (brown eyes dominant , blue eyes recessive) Dd- Dimples ( dominant) Cc/cc- Cleft chin (Dominant) Sarah BbDdcc James bbDdCc What is the probability that Sarah and James will have a baby girl with blue eyes and dimplesJohn and Sue are expecting a child, but are concerned about a rare autosomal recessive disease that is present in both of their families. In the pedigree, John is represented as individual III‑11 and Sue is represented as individual III‑12; both are unaffected. John's sister, III‑10, and Sue's brother, III‑13, both do not show evidence of the disease, but John's paternal grandmother and Sue's maternal grandfather both had the disease. What is the probability that neither John nor Sue is a carrier?Is the trait dominant or recessive for this pedigree? _____________. Write the genotype for each individual. (Use the letter B)
- Karen and Steve each have a sibling with sickle-cell disease.Neither Karen nor Steve nor any of their parents have thedisease, and none of them have been tested to see if they carrythe sickle-cell allele. Based on this incomplete information,calculate the probability that if this couple has a child, thechild will have sickle-cell disease.Wilson’s disease is an inherited disorder in which there is too much copper in the body’s tissue. It is inherited in an autosomal recessive manner. Below are pedigrees from two families where some members of a family have Wilson’s disease. Neither Hillary nor Justin have Wilson’s disease. If they have a child, what is the chance this child will have Wilson’s disease?A young couple went to see a genetic counselor because each had a sibling with cystic fibrosis. (Cysticfibrosis is a recessive disease, and neither member ofthe couple nor any of their four parents is affected.)a. What is the probability that the female of thiscouple is a carrier?b. What are the chances that their child will havecystic fibrosis?c. What is the probability that their child will be acarrier of the cystic fibrosis disease allele?