Kinetic versus thermodynamic. The reaction of NADH with oxygen to produce NAD+NAD* and H2OH2O is very exergonic, yet the reaction of NADH and oxygen takes place very slowly. Why does a thermodynamically favorable reaction not occur rapidly?

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions
Section21.SE: Something Extra
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Kinetic versus thermodynamic. The reaction of NADH with oxygen to
produce NAD+NAD* and H2OH2O is very exergonic, yet the
reaction of NADH and oxygen takes place very slowly. Why does a
thermodynamically favorable reaction not occur rapidly?
Transcribed Image Text:Kinetic versus thermodynamic. The reaction of NADH with oxygen to produce NAD+NAD* and H2OH2O is very exergonic, yet the reaction of NADH and oxygen takes place very slowly. Why does a thermodynamically favorable reaction not occur rapidly?
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