Let's imagine that in a drug design project a problem is encountered with the low water solubility of a lead compound. The compound has the low melting point of 41-43°C, and a log P value of 4.95. The compound does not possess any ionizable basic or acidic functional groups. Suggest two kinds of modification that the design team could introduce to increase the water solubility of the lead compound. Modification 1: Modification 2:

Let's imagine that in a drug design project a problem is encountered with the low water solubility of a lead compound. The compound has the low melting point of 41-43°C, and a log P value of 4.95. The compound does not possess any ionizable basic or acidic functional groups. Suggest two kinds of modification that the design team could introduce to increase the water solubility of the lead compound. Modification 1: Modification 2:

Chemistry by OpenStax (2015-05-04)

1st Edition

ISBN:9781938168390

Author:Klaus Theopold, Richard H Langley, Paul Flowers, William R. Robinson, Mark Blaser

Publisher:Klaus Theopold, Richard H Langley, Paul Flowers, William R. Robinson, Mark Blaser

Chapter15: Equilibria Of Other Reaction Classes

Section: Chapter Questions

Problem 11E: The Handbook of Chemistry and Physics (http://openstaxcollege.org/l/16Handbook) gives solubilities...

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