Answered: Ligand A binds to protein P with a…

Ligand A binds to protein P with a dissociation constant, Kd = 1.5 uM. (a) What concentration of A is required in order for half

Fundamentals Of Analytical Chemistry

9th Edition

ISBN:9781285640686

Author:Skoog

Publisher:Skoog

Chapter17: Complexation And Precipitation Reactions And Titrations

Section: Chapter Questions

Problem 17.1QAP

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Concept explainers

Organometallic compounds of d-block elements

The transition metals can form complexes since they have vacant d orbitals. They are also termed Coordination compounds. The organometallic compounds of the transition metals could be used as catalysts as well as reagents. For example, organocadmium, organozinc, organocopper, Grignard are used as the reagents for several reactions. Most of the complexes of organo transition metals are used as catalysts for many organic transformation reactions.

Question

Ligand A binds to protein P with a dissociation constant, Kd = 1.5 uM.
(a) What concentration of A is required in order for half of P to be bound?
Use the equation: [PA]/ PTot = [A]/ Kd+[A]

b)What concentration of A is required for 90% of P to be bound?

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