Match Genotype With Phenotype Consider a newly discovered organism that is bioluminescent. Scientists studying this animal have discovered that there are two enzymes necessary for the animal to glow, encoded by the bright and red genes. Furthermore, scientists have confirmed that for bioluminescence to be displayed, an individual must have at least one copy of the dominant allele for each gene, (B and R). Match the genotypes with their correct phenotypes, glowing or nonglowing. BBRR Bbrr bbrr Glowing BbRR bbRR BbRr bbRr Non-glowing BBRr BBrr
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- Equalizing the Expression of X Chromosome Genes in Males and Females Individuals with an XXY genotype are sterile males. If one X is inactivated early in embryogenesis, the genotype of the individual effectively becomes XY. Why will this individual not develop as a normal male?Gene Interaction and Epistasis Hair color is due to the presence of melanin. There are two types of melanin produced by melanocytes. One is eumelanin, which is responsible for black (homozygous), brown (heterozygous), and blond (recessive) hair colors. The other is pheomelanin, which is responsible for red hair color. During melanin synthesis, MCR1gene converts pheomelanin to eumelanin. However, a variant of the MCR1 gene (MCR1variant), prevents this conversion. A cross between a blond-haired mother and a red-haired father produced 100% brown-haired children. When they came of age, one child married a double heterozygote, and both were blessed with 7 children; 2 with black hair, 2 with brown hair, 1 with blond hair, and 2 with red hair. Using the 7-step method, determine the genotypes of the P1, the F1, and the F2s. BOX your answers (if handwritten) or HIGHLIGHT your answers (if encoded). STEP 1: ________________________________________________________ STEP 2:…researchers have been able to clonemammals by fusing a cell having a diploid nucleus (i.e., a somaticcell) with an egg that has had its nucleus removed.A. With regard to maternal effect genes, would the phenotype ofsuch a cloned animal be determined by the animal that donatedthe egg or by the animal that donated the somatic cell? Explain.B. Would the cloned animal inherit extranuclear traits from theanimal that donated the egg or from the animal that donated thesomatic cell? Explain.C. In what ways would you expect this cloned animal to be similarto or different from the animal that donated the somatic cell? Isit fair to call such an animal a clone of the animal that donatedthe diploid nucleus?
- . The production of pigment in the outer layer of seedsof corn requires each of the three independently assorting genes A, C, and R to be represented by at leastone dominant allele, as specified in Problem 64. Thedominant allele Pr of a fourth independently assortinggene is required to convert the biochemical precursorinto a purple pigment, and its recessive allele pr makesthe pigment red. Plants that do not produce pigmenthave yellow seeds. Consider a cross of a strain of genotype A/A ; C/C ; R/R ; pr/pr with a strain of genotypea/a ; c/c ; r/r ; Pr/Pr.a. What are the phenotypes of the parents?b. What will be the phenotype of the F1?c. What phenotypes, and in what proportions, willappear in the progeny of a selfed F1?d. What progeny proportions do you predict from thetestcross of an F1?Female fruit flies homozygous for the X-linked white-eye alleleare crossed to males with red eyes. On very rare occasions, an offspringof such a cross is a male with red eyes. Assuming these rareoffspring are not due to a new mutation in one of the mother’s Xchromosomes that converted the white-eye allele into a red-eyeallele, explain how a red-eyed male arises.In humans, two genes encoding the opsin visual pigmentsthat are sensitive to green and red wavelengths of lightare found adjacent to one another on the X chromosome.They encode proteins that are 96 percent identical.Nonprimate mammals possess just one gene encoding anopsin sensitive to the red/green wavelength.a. Offer one explanation for the presence of the twoopsin genes on the human X chromosome.b. How would you test your explanation further andpinpoint when in evolutionary history the second genearose?
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- . Considering the yellow and green pea color phenotypes studied by Gregor Mendel:a. What is the biochemical function of the proteinthat is specified by the gene responsible for thepea color phenotype?b. A null allele of a gene is an allele that does notspecify any of the biochemical function that thegene normally provides. Of the two alleles Y and y,which is more likely to be a null allele?c. In terms of the underlying biochemistry, why is theY allele dominant to the y allele?d. Why are peas that are yy homozygotes green?e. The amount of the protein specified by a gene isroughly proportional to the number of functionalcopies of the gene carried by a cell or individual.What do the phenotypes of YY homozygotes, Yyheterozygotes, and yy homozygotes tell us aboutthe amount of the Sgr enzyme (the product of thepea color gene) needed to produce a yellow color?Drosophila P elements were discovered because ofa phenomenon called hybrid dysgenesis—sterilityof particular hybrid progeny. When scientists in the1970s crossed their D. melanogaster laboratorystrains to flies of the same species obtained fromnatural environments outside the lab, they observeda remarkable result: The progeny of the crosseswere sterile, but only when outside males werecrossed with lab strain females. Progeny resultingfrom crosses of outside females with lab maleswere perfectly normal.DNA analysis revealed that while the genomesof the outside flies contain P elements, the lab flygenomes have none. Apparently, P elements spreadthroughout the wild population of D. melanogasterafter the capture of the originators of present-daylaboratory strains over 100 years ago.a. The hybrid progeny are sterile because their germline cells have a high rate of mutation and chromosomal rearrangement (dysgenesis) caused by highrates of P element mobilization. Explain howP element movement…. The human IGF2 gene is autosomal and maternallyimprinted. Copies of the gene received from themother are not expressed, but copies received fromthe father are expressed. You have found two allelesof this gene that encode two different forms of theIGF2 protein distinguishable by gel electrophoresis.One allele encodes a 60K (Kilodalton) blood protein;the other allele encodes a 50K blood protein. In ananalysis of blood proteins from a couple named Billand Joan, you find only the 60K protein in Joan’sblood and only the 50K protein in Bill’s blood. Youthen look at their children: Jill is producing only the50K protein, while Bill Jr. is producing only the 60Kprotein.a. With these data alone, what can you say about theIGF2 genotype of Bill Sr. and Joan?b. Bill Jr. and a woman named Sara have two children, Pat and Tim. Pat produces only the 60K protein and Tim produces only the 50K protein. Withthe accumulated data, what can you now say aboutthe genotypes of Joan and Bill Sr.?