Methylation can alter the process of gene expression because: B. By causing DNA to coil more tightly. A. By derailing the cellular transcription machinery. C. By removing the gene from the genome altogether. D. ALL answers A, B and C are correct. E. Only answers A and B are correct, but not C.
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- A biology professor at a prestigious university stated to his introductory class that "Today, a basic understanding of DNA and genetics is as important as a basic understanding of computers and the internet."Based upon what you have learned about DNA and gene expression in this module, how could you make a case to support this statement?a) What is a gene promoter? b) What proteins bind to a promoter? c) What do those proteins do to control gene expression?Which of the following best represents the central dogma of geneexpression?a. During transcription, DNA codes for polypeptides.b. During transcription, DNA codes for mRNA, which codes forpolypeptides during translation.c. During translation, DNA codes for mRNA, which codes forpolypeptides during transcription.d. none of the above
- Which of the following is the best description of a transcription factor? A. A protein that brings the correct nucleotides to RNA polymerase B. A protein that binds to specific DNA sequences C. A DNA sequence that binds to RNA polymerase D. A modification that is made to mRNA to help it be exported from the nucleus. .Which of the following is true of transcription factors? A)The same transcription factors are found in all cell types. B)They can increase or decrease gene expression. C)They are a type of cis-acting element. D)They bind only to promoters.CRISPR is a powerful gene editing tool because a. the programmable enzyme (Cas9) can find an exact sequence and make a cut at precise nucleotide. b. it can be applied to all types of cells. c. it has both genetic editing and epigenetic functions. d. it is inexpensive. e. all of these are correct
- Which among the following statements is not true about mutations? * a.) It may either occur at the chromosomes or at the sequence of nucleic acids. b.) It is caused either by mutagens or through hereditary genes. c.) All mutations cause diseases and disorders in the developing organism. d.) All mutations causes a change in the structure or sequence of the genetic material.You are curious to identify the region of the gene X sequence that serves as an enhancer for gene expression. Design an experiment to investigate this issue.If a mutation occurred in a control element sequence associated with a particular gene, which of the following would be a likely consequence of this? A. This mutation is not likely to affect the expression of the associated gene, because RNA polymerase does not bind to control elements. B. This will likely affect the expression of the associated gene because it will loosen the coiling of chromatin at this site. C. The expression of the associated gene will be affected because this change will result in a nonsense mutation. D. This mutation is not likely to affect the expression of the associated gene, since control elements are noncoding sequences. E. The associated gene's expression would likely be affected, since this mutation would change the ability of at least one transcription factor to bind.
- Can one transcription factor sometimes act as a repressor and sometimes act as an activator? a. Yes, but it depends on where the transcription factor binds in the promoter b. Yes, but it depends on other proteins that might act with the transcription factor c. No, transcription factors are always either activators or repressors d. Yes, but only if a mutation happensWhat strategy does a genetically encoded calcium indicator look like to allow fluorescence imaging of only one cell type in an acute slice of the brain? A.The use of fluorescent protein expression inhibitors in other cells B.The injection of a recombinant virus causing the death of other cells C.The use of a promoter specific to these cells D.Activation of membrane receptors specific to these cellsDNA methylation is A. heritable and generally activates gene expression. B. heritable and generally represses gene expression. C. not heritable and generally represses gene expression. D. not heritable and generally activates gene expression.