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- Which of the following mutations in the protein-coding region of a gene is more likely to lead to complete loss of function of the encoded protein: an insertion of six nucleotides or a deletion of two nucleotides? Briefly explain your answer.Which of the following terms refer to the case when a mutation results in a significant decrease or a complete loss of the functional activity of a gene product? a. gain-of-function mutation b. loss-of-function mutationA single base mutation in a gene may not 'always'result in loss of grain of function?
- If the coding region of a gene (the exons) contains 2,100 base pairs of DNA, would a missense mutation cause a protein to be shorter, longer, or the same length as the normal 700 amino acid proteins? What would be the effect of a nonsense mutation? A sense mutation?The pre-mRNA transcript and protein made by several mutant genes were examined. The results are given below. Determine where in the gene a likely mutation lies: the promoter region, exon, intron, cap on mRNA, or ribosome binding site. a. normal-length transcript, normal-length nonfunctional protein b. normal-length transcript, no protein made c. normal-length transcript, normal-length mRNA, short nonfunctional protein d. normal-length transcript, longer mRNA, shorter nonfunctional protein e. transcript never madeFor a specific type of mutation at a given location in a particular gene, identify whether it will affect the size of the mRNA, the protein, or both. How would the mutant appear on a gel in comparison to the original
- Name three different types of loss of function mutations and in each case explain how the mutation exerts a loss of function effect on a geneExplain point mutations and frameshift mutations. Which is more apt to disrupt the structure and or function of a protein coded for by a gene? Why?Which of the following mutations would likely have the greatest negative impact on the protein product of a gene? Group of answer choices a single base deletion close to the end of the coding region of a gene a single base insertion just after the start of the coding region of the gene a deletion of three bases near the middle of the gene a base-pair substitution
- The first product of genome expression is transcriptome but what happens if the RNA of the genes are not activated at a certain time?TRUE OR FALSEErrors in transcription can lead to silent mutations encoding the same amino acid or an altered protein that retains its functionality.Which of the following mutations in a gene will most likely have the greatest impact on the resulting protein? 1.A point mutation in the DNA sequence that codes for the stop codon 2.A missense mutation in the DNA sequence that codes for the start codon 3.A 2-base deletion in the DNA sequence that codes for the 3’ UTR 4.A nonsense mutation in the DNA sequence that codes for the 5’ UTR