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The pre-mRNA transcript and protein made by several mutant genes were examined. The results are given below. Determine where in the gene a likely mutation lies: the promoter region, exon, intron, cap on mRNA, or ribosome binding site. a. normal-length transcript, normal-length nonfunctional protein b. normal-length transcript, no protein made c. normal-length transcript, normal-length mRNA, short nonfunctional protein d. normal-length transcript, longer mRNA, shorter nonfunctional protein e. transcript never made

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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Chapter
Section
BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 9, Problem 10QP
Textbook Problem
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The pre-mRNA transcript and protein made by several mutant genes were examined. The results are given below. Determine where in the gene a likely mutation lies: the promoter region, exon, intron, cap on mRNA, or ribosome binding site.

  1. a. normal-length transcript, normal-length nonfunctional protein
  2. b. normal-length transcript, no protein made
  3. c. normal-length transcript, normal-length mRNA, short nonfunctional protein
  4. d. normal-length transcript, longer mRNA, shorter nonfunctional protein
  5. e. transcript never made

a.

Summary Introduction

To determine: Whether the mutation lies in the promoter region, exon, intron, cap on mRNA or ribosomal binding site if normal length transcript, and a normal nonfunctional protein is formed.

Introduction: Mutation is the change in the genetic sequence (DNA) of the cell. They can occur spontaneously during DNA replication or may be induced by external environmental factors like chemicals or radiation. The site of mutations can determine the fate of gene expression.

Explanation of Solution

The promoter region is responsible for the attachment of the transcription machinery. Hence, the formation of a normal length transcript suggests that the mutation is not in the promoter region. Further, the normal length protein indicates that the mutation is not in the termination sequences...

b.

Summary Introduction

To determine: The site of mutation if normal length transcript is formed and no protein is made.

Introduction: The process of formation of protein from mRNA is called translation. The mRNA once transcribed has sequences that responsible for the binding of the ribosome. The ribosomes are proteins that bind to mRNA and make a primary protein molecule.

c.

Summary Introduction

To determine: The site of mutation if a normal length transcript, normal length mRNA, and a short nonfunctional protein are formed.

Introduction: The genetic information is coded by four nucleotides in the form of triplets. The triplet of the nucleotides code for different amino acids and are referred to as codons. Additionally, these codons also code for the start of the primary sequence of the protein and its end. There are three stop codons and one start codon.

d.

Summary Introduction

To determine: The mutation site if normal length transcript, longer mRNA, and shorter nonfunctional protein are formed.

Introduction: Eukaryotic genes contain a coding region called as exon and a noncoding region called as an intron. After transcription, the introns are removed by a process called splicing resulting in a contiguous coding sequence.

e.

Summary Introduction

To determine: The mutation site if no transcript is made.

Introduction: Transcription of the DNA into mRNA transcript is carried out by transcription enzymes. The enzymes bind at the promoter sequence of the gene and form an mRNA transcript. The mRNA then after splicing translates into a primary protein sequence.

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