Nicotine is a dibasic alkaloid. A pKa value of 8 is associated with the aliphatic nitrogen in the 5-membered saturated ring, and a pka of 3 is associated with the heterocyclic nitrogen contained within the aromatic 6-membered ring. Nitrogen containing aromatic heterocycles are typically much less basic than are aliphatic or alicyclic amines. Which of the following forms of nicotine is predicted to be most abundant in water solution at pH 6? A. N CH3 B. H÷N¬ CH3 C. H N CH3 D. N* H -N-H CH3

Nicotine is a dibasic alkaloid. A pKa value of 8 is associated with the aliphatic nitrogen in the 5-membered saturated ring, and a pka of 3 is associated with the heterocyclic nitrogen contained within the aromatic 6-membered ring. Nitrogen containing aromatic heterocycles are typically much less basic than are aliphatic or alicyclic amines. Which of the following forms of nicotine is predicted to be most abundant in water solution at pH 6? A. N CH3 B. H÷N¬ CH3 C. H N CH3 D. N* H -N-H CH3

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter22: Reactions Of Benzene And Its Derivatives

Section: Chapter Questions

Problem 22.63P

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