N,N-Dimethyltryptamine (DMT) is a powerful hallucinogenic that is being trialled (in low doses) to treat depression, mania and anxiety disorders. In the clinical trials where the researchers aim to test this compound on people, it is found that the drug (drawn below) is poorly absorbed from the gut into the blood plasma. Further, the drug has poor solubility in the blood as it is very non-polar (over-all). Name a reaction that could assist with solubilising DMT in the blood. N O Inject DMT directly into the blood intravenously, to avoid uptake via the gut O Take DMT via the respiratory route (smoke or inhale it) to increase uptake into the blood O Dissolve DMT in an oil immersion to increase its uptake in the gut O React with HCI to afford the hydrochloride salt of each basic amine, thus increasing water solubility ZI

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N,N-Dimethyltryptamine (DMT) is a powerful hallucinogenic that is being trialled (in low doses) to treat depression,
mania and anxiety disorders. In the clinical trials where the researchers aim to test this compound on people, it is
found that the drug (drawn below) is poorly absorbed from the gut into the blood plasma. Further, the drug has poor
solubility in the blood as it is very non-polar (over-all). Name a reaction that could assist with solubilising DMT in the
blood.
O Inject DMT directly into the blood intravenously, to avoid uptake via the gut
Take DMT via the respiratory route (smoke or inhale it) to increase uptake into the blood
Dissolve DMT in an oil immersion to increase its uptake in the gut
O React with HCI to afford the hydrochloride salt of each basic amine, thus increasing water solubility
ZI
Oooo
Transcribed Image Text:N,N-Dimethyltryptamine (DMT) is a powerful hallucinogenic that is being trialled (in low doses) to treat depression, mania and anxiety disorders. In the clinical trials where the researchers aim to test this compound on people, it is found that the drug (drawn below) is poorly absorbed from the gut into the blood plasma. Further, the drug has poor solubility in the blood as it is very non-polar (over-all). Name a reaction that could assist with solubilising DMT in the blood. O Inject DMT directly into the blood intravenously, to avoid uptake via the gut Take DMT via the respiratory route (smoke or inhale it) to increase uptake into the blood Dissolve DMT in an oil immersion to increase its uptake in the gut O React with HCI to afford the hydrochloride salt of each basic amine, thus increasing water solubility ZI Oooo
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