но HO OH benzyl salicylate PolyAspirin но° OH .CI salicylic acid sebacic acid sebacoyl chloride

Organic And Biological Chemistry
7th Edition
ISBN:9781305081079
Author:STOKER, H. Stephen (howard Stephen)
Publisher:STOKER, H. Stephen (howard Stephen)
Chapter5: Carboxylic Acids, Esters, And Other Acid Derivatives
Section: Chapter Questions
Problem 5.107EP
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Researchers at Rutgers University have developed biocompatible polymers that degrade into nonsteroidal anti-inflammatory drugs. For example, the reaction of two equivalents of benzyl salicylate and one equivalent of sebacoyl chloride forms a poly(anhydride ester) called PolyAspirin, which hydrolyzes to salicylic acid (an anti-inflammatory agent) and sebacic acid, which is excreted. This technology can perhaps be used for localized drug delivery at specific sites of injury. What is the structure of PolyAspirin?

но
HO
OH
benzyl salicylate
PolyAspirin
но°
OH
.CI
salicylic acid
sebacic acid
sebacoyl chloride
Transcribed Image Text:но HO OH benzyl salicylate PolyAspirin но° OH .CI salicylic acid sebacic acid sebacoyl chloride
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