Although codeine occurs in low concentration in the opium poppy, most of the codeine used in medicine is prepared from morphine (the principal component of opium) by the following reaction. Explain why selective methylation occurs at only one OH in morphine to give codeine. Codeine is a less potent and less addictive analgesic than morphine. но. CH,0. [1 кон H [2] CH3I H. CH3 H Ho morphine H. CH3 Ho codeine

Organic Chemistry
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ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter27: Biomolecules: Lipids
Section27.SE: Something Extra
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Although codeine occurs in low concentration in the opium poppy, most of the codeine used in medicine is prepared from
morphine (the principal component of opium) by the following reaction. Explain why selective methylation occurs at only one
OH in morphine to give codeine. Codeine is a less potent and less addictive analgesic than morphine.
но.
CH,0.
[1 кон
H
[2] CH3I
H.
CH3
H
Ho
morphine
H.
CH3
Ho
codeine
Transcribed Image Text:Although codeine occurs in low concentration in the opium poppy, most of the codeine used in medicine is prepared from morphine (the principal component of opium) by the following reaction. Explain why selective methylation occurs at only one OH in morphine to give codeine. Codeine is a less potent and less addictive analgesic than morphine. но. CH,0. [1 кон H [2] CH3I H. CH3 H Ho morphine H. CH3 Ho codeine
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