Myo-inositol, the most prominent naturally occurring form of inositols, is a carbocyclic polyol that plays an important role as the structural basis for a number of secondary messengers in eukaryotic cells. It is generated in vivo from the aldol cyclization of glucose-6-phosphate to myo-inositol-1-phosphate OPO,2-OHHOmyo-inositol-1-phosphate synthaseOH2-03POHO""OHHO(1)a-D-glucose-6-phosphatemyo-inositol-1-phosphatea. What is the absolute configuration (R or S) at C-2 ofnaturally occurring a-D-glucose-6-phosphate?b. Using any unambiguous notation, drawthe enantiomer (mirror image) of myo-inositol-1-phosphate. Place your answerin the space provided here.

Absolute configuration is R. This can be calculated based on the CIP rule.

OPO,2- \OH HO myo-inositol-1-phosphate synthase OH 2-03PO HO "OH HO (1 ÕH a-D-glucose-6-phosphate myo-inositol-1-phosphate a. What is the absolute configuration (R or S) at C-2 of naturally occurring a-D-glucose-6-phosphate? b. Using any unambiguous notation, draw the enantiomer (mirror image) of myo- inositol-1-phosphate. Place your answer in the space provided here.

OPO,2- \OH HO myo-inositol-1-phosphate synthase OH 2-03PO HO "OH HO (1 ÕH a-D-glucose-6-phosphate myo-inositol-1-phosphate a. What is the absolute configuration (R or S) at C-2 of naturally occurring a-D-glucose-6-phosphate? b. Using any unambiguous notation, draw the enantiomer (mirror image) of myo- inositol-1-phosphate. Place your answer in the space provided here.

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter23: Enzymes

Section: Chapter Questions

Problem 23.9P

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