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A:
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- Two mobile electron transfer carriers are present in the inner mitochondrial membrane. Name these two carriers.Describe the movement of protons that is caused by the action of the mitochondrial electron transport chain and explain why more ATP can be generated from the addition of NADH to the system as opposed to succinate.The NADH produced in the cytosol is transported to the mitochondrial intermembrane space via the
- In step 6 of the Krebs cycle succinate ___ to fumerate a reaction that takes place in the ___ oxidizes ;inner mitochondrial membrane reduces ;mitochondrial matrix reduces; inner mitochondrial membrane Oxidizes; mitochondrial matrixWhy does mitochondrial NADH yields more ATPs than cytosolic NADH?NADH produced in the glycolytic pathway cannot enter the mitochondrial membrane, so the shuttle systems are utilized to deliver the electrons to the ETC. Using a flowchart, illustrate and differentiate the flow of the electrons in the ETC when electrons from cytosolic NADH are delivered to the ETC via the two shuttle systems.
- Uncoupling agents are proteins spanning the inner mitochondrial membrane that allow protons to pass through the membrane and bypass the channel of ATP synthase. Describe the consequences to the proton gradient and ATP production.?Under typical conditions, how many protons are pumped across the mitochondrial intermembrane for each molecule of NADH that is oxidized (assuming its electrons are passed all the way to O2 by the respiratory chain)? 1. 1 2. 6 3. 10 4. 100Which of the following is the major source of electrons that flow through the mitochondrial electron transport chain? (a) H2 0 (b) ATP (c) NADH (d) ATP synthase (e) coenzyme A
- Which of the following components of the mitochondrial electron transport chain is not integral to the inner mitochondrial membrane (of a typical eukaryotic cell)? the cytochrome c oxidase complex coenzyme Q (ubiquinone) the cytochrome b-c1 complex cytochrome c the cytochrome a-a3 complexDescribe the processes that are driven by mitochondrial electron transport.In the section dealing with “NAD+ in disease” it is mentioned that metabolomics results indicate that impaired mitochondrial function contributes to some of the mentioned diseases. Which metabolites can potentially accumulate when complex I of the electron transport chain is defective? Use Fig 1 for guidance.