Please help me in detail. for molecular Mechanism of ATP versus GTP selectivity of adenylate kinase, Draw a reaction scheme that includes both the substrate and the inhibitor under study here. Be sure to label KI, Ks, kp
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1F. Please help me in detail. for molecular Mechanism of ATP versus GTP selectivity of adenylate kinase, Draw a reaction scheme that includes both the substrate and the inhibitor under study here. Be sure to label KI, Ks, kp
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- 1G. Please help me in detail. For Molecular Mechanism of ATP versus GTP selectivity of adenylate kinase, Write an expression for the reaction velocity.1J. Please help me in detail. for molecular Mechanism of ATP versus GTP selectivity of adenylate kinase4. a. Calculate the KM (Michaelis constant) and the vmax (the maximum initial rate) for both substrates (sphingosine and ATP). Show your work, and be careful about units. b. threo-dihydrosphingosine, a stereoisomer of sphingosine, is an inhibitor of sphingosine kinase. What kind of inhibitor (competitive, uncompetitive, noncompetitive) is threo-dihydrosphingosine? Citing information from the Lineweaver-Burke plots, explain how you can tell.
- Functional and structural analysis indicates that Gleevec is an ATPcompetitive inhibitor of the Bcr-Abl kinase. In fact, many kinase inhibitors under investigation or currently marketed as drugs are ATP competitive. Can you suggest a potential drawback of drugs that utilize this particular mechanism of action?Please refer to the model, the answer may be brief.. thank you so much for answering both... i appreciate it1. Explain the mechanism of action of the adenyl cyclic system using a schematic diagram. 2. Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of action1E In terms of binding adenylate kinase, the Kd for ATP is ~50 M and the KI for GMP-PCP is ~50 nM. Explain how this may be possible in terms of molecular interactions. Name 4 different types of molecular interactions that may contribute to the increased binding affinity exhibited by GMP-PCP. Please help me in details
- b) Following this experiment, you would like to elucidate the mechanism of action of pyruvate kinase. Unfortunately, the crystal structure of pyruvate kinase is not available, which requires the enzyme to be modelled based on the available three-dimensional structures of related enzymes. Suggest a bioinformatics approach that can be conducted to perform this study.1B. please help me in detail. Draw a graph of free energy G (y-axis) vs reaction progress (x-axis) that illustrates what the kinase is doing in terms of the free energy by showing (i) the substrate (also label what the substrate is [it’s name]), (ii) the products (also give the name of the products), (iii) draw and label the uncatalyzed and catalyzed reactions, and be sure that the parts of the graph are properly labeled..Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of action. Note: Explain it conscisely and precisely
- 1C One of the major findings of this study is that GTP arrests the enzyme. Draw (i) the natural substrate ATP; (ii) the substrate analog, GTP, and (iii) the GMP-PCP molecule. Indicate where they are different. For each molecule, indicate where the hydrolysable (scissile bond) is located. Please help meFollowing this experiment, you would like to elucidate the mechanism of action of pyruvatekinase. Unfortunately, the crystal structure of pyruvate kinase is not available, whichrequires the enzyme to be modelled based on the available three-dimensional structures ofrelated enzymes. Suggest a bioinformatics approach that can be conducted to perform thisstudy.If intracellular [ATP] = 5 mM, [ADP] = 0.5 mM, and [Pi] = 1.0 mM, calculate the concentration of AMP at pH 7 and 25°C under the condition that the adenylate kinase reaction is at equilibrium.