Programmed for IgM expression No loss of DNA Loss of DNA Variable region IgM IgD IgG IgE IgA Segment of DNA deleted B-cell DNA Programmed for IgM expression Programmed for IgG expression Variable region IgM IgD IgG IgE IgA Variable region IgG IgE IgA B-cell DNA B-cell DNA Plasma cells that develop from this B cell will produce IgM because that constant region gene segment is first in line. Plasma cells that develop from this B cell will produce IgG because the DNA loss now puts that constant region gene segment first in line. FIGURE 15.15 Class Switching Naive B cells are programmed to produce IgM antibodies. Activated B cells undergo class switching. Class switching does not alter the variable region and therefore has no effect on the antibody specificity. The plasma cells descended from B cells in lymph nodes most commonly produce IgG after class switching.

Programmed for IgM expression No loss of DNA Loss of DNA Variable region IgM IgD IgG IgE IgA Segment of DNA deleted B-cell DNA Programmed for IgM expression Programmed for IgG expression Variable region IgM IgD IgG IgE IgA Variable region IgG IgE IgA B-cell DNA B-cell DNA Plasma cells that develop from this B cell will produce IgM because that constant region gene segment is first in line. Plasma cells that develop from this B cell will produce IgG because the DNA loss now puts that constant region gene segment first in line. FIGURE 15.15 Class Switching Naive B cells are programmed to produce IgM antibodies. Activated B cells undergo class switching. Class switching does not alter the variable region and therefore has no effect on the antibody specificity. The plasma cells descended from B cells in lymph nodes most commonly produce IgG after class switching.

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Description: How would this illustration change if it showed class switching by B cells residing in Peyer’s patches? Programmed forIgM expressionNo loss of DNA Loss of DNAVariable regionIgM IgD IgG IgE IgASegment of DNAdeletedB-cell DNAProgrammed forIgM expressio

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter7: Development And Sex Determination

Section: Chapter Questions

Problem 18QP: Equalizing the Expression of X Chromosome Genes in Males and Females Males have only one X...

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