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- Ligand binding and response. The following question involves the ligand binding to a receptor and the receptor's response to that ligand. What ligand concentration would be required for a full agonist with a KD of 8 nM to achieve a response of 0.75?Provide a diagram of the EPH RECEPTOR B2 (EPHB2) structure. Give bioinformatics structure1H. please help me in detail. For molecular Mechanism of ATP versus GTP selectivity of adenylate kinase
- How GTN works? What are the combination drug therapy are used in managing the hyperlipidemia? Please briefly explain at your own words.Need help. Plz explain briefly Describe in detail with the aid of diagrams the use of chemical shift perturbation mapping to identify ligand binding sites on a protein.Need help Intaractions of FAK kinase which directly depend on the tyrosine residue 397 (Y397) are inhibbited by a chemical compound in cancercells. Intaraction of FAK kinase with what proteins are blocked by this inhibition? (please give a listt of them all, and that's it)
- (ii) Considering the entropic contributions to ligand-receptor binding discuss how the strength of ligand-receptor binding for the molecule below may be affected by changing the double bond (1) to a single bond and removal of the hydroxyl group (2)One of the initial symptoms a person can have for COVID-19 is the lost of taste and smell. Give a potential mechanism, including which portion of the reflex arc is being impacted, of how COVID is able to have this impact. Use an online source to support your argument.CTP inhibits ATCase; however, the inhibition is not complete. Can you suggest another molecule that might enhance the inhibition of ATCase?
- SIGNALS AND TARGETS. Listed below are sample polypeptides/proteins with their signal molecule/peptide. Answer the questions that follow. If you are asked to give the amino acid sequence, provide the sequence using the three-letter names of the amino acids (eg. ser-ala-met). Catalase with H2N-...KERINGKERIANGEKSAMSKL-COOH What is the name of the specific receptor of this polypeptide? The receptor may also have what alternative function?Give typed full explanation Bradykinin is a plasma peptide and a potent vasodilator. It is derived from a large precursor called kininogen. Bradykinin has the following structure: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg. Which amino acids in bradykinin have reactive functional groups in their side chains? What are these reactive functional groups? What does the name "kininogen" indicate?Choices for each phrases: a, b, y, t, v, e; gtp, cgt, atp, adp, camp, catp; gtp, gdp, atp, adp, camp, catp; histamine kinase, gaunylyl cyclamen, phosphorylation, adenylyl cyclase