Reaction 25.5 Hb (aq) + Glucose (aq) ⇄ Hb-Glucose (aq)  A patient’s blood glucose levels can fluctuate significantly (especially before and after meals). Alternatively, the diabetic A1C marker can be used which measures the percentage of hemoglobin-glucose (Hb-Glucose) in a patient's blood. Using Reaction 25.5, explain why clinicians can use the A1C marker (i.e. levels of Hb-Glucose) in a patient’s blood as a proxy for glucose levels in the blood?

Introduction to General, Organic and Biochemistry
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Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
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Chapter23: Enzymes
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Reaction 25.5 Hb (aq) + Glucose (aq) ⇄ Hb-Glucose (aq)

  1.  A patient’s blood glucose levels can fluctuate significantly (especially before and after meals). Alternatively, the diabetic A1C marker can be used which measures the percentage of hemoglobin-glucose (Hb-Glucose) in a patient's blood. Using Reaction 25.5, explain why clinicians can use the A1C marker (i.e. levels of Hb-Glucose) in a patient’s blood as a proxy for glucose levels in the blood?
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