In the "Catalysis by Preferential Transition State Binding" mechanism, the substrate perfectly fits with the enzyme binding site after its geometry gets changed. Who does it? And how?

Chemistry: The Molecular Science
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ISBN:9781285199047
Author:John W. Moore, Conrad L. Stanitski
Publisher:John W. Moore, Conrad L. Stanitski
Chapter11: Chemical Kinetics: Rates Of Reactions
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 In the "Catalysis by Preferential Transition State Binding" mechanism, the substrate perfectly fits with the enzyme binding site after its geometry gets changed. Who does it? And how?

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