:&;$;$$;$;:$:$ Retrosynthetic Analysis QuestionQ1- In the box draw the two possible starting materials you could use to synthesize the followingmolecules using the reaction indicated.Nucleophilic Subsitution ReactionNucleophilic Subsitution ReactionNucleophilic Subsitution ReactionNucleophilic Subsitution Reactionfollowed Acid Catalyzed Hydrationof AlkyneNucleophilic Subsitution Reactionfollowed by hydroborationOxidation of AlkyneH

Step 1: (I)Step 2: (II)Step 3: (III)Step 4: (IV)Step 5: (V)

Answered: Retrosynthetic Analysis Question Q1- In…

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter21: Nas: Nucleophilic Aromatic Substitution

Section: Chapter Questions

Problem 8E

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Consider the series of the trans effect: CO, CN-, C2H4 > PR3, H-, CH3- > C6H5- > NO2-, SCN-, I- > Br- >Cl- > py > NH3 > H20 What would be the major product of the following reaction? Select one:
Propose how you could synthesize the following compound, using a substitution reaction. Propose a nucleophile, a solvent, and an electrophile. Show the curved-arrow mechanism of the reaction. Finally, draw the transition state of the reaction.
Match the questions with the correct descriptions below: Sn2, E2 E1cb Sn1, E1 (anti) E2, E1cb Sn1, E1 2 steps poor leaving group 2 carbons removed from a carbonyl group carbanion intermediate 3°>allylic, benzylic>2°>1°>CH₃ carbocation intermediate Ist order reaction (r=k[RX]) H-X anti no intermediate 2nd order reaction (r=k[RX][Nu]) polar aprotic solvent
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Below is the equation for a nucleophilic substitution reaction and some experimental data. CH3CH2Br + CH3COO- ⇌ CH3CH2CO2CH3 + Br- Rate = k [CH3CH2Br][CH3COO-] Which mechanism would best fit the data?
1. What type of reaction is occuring in step 3? (halogenation, hydrohalogenation, reduction, keto–enol tautomerism, dehydrohalogenation, acid-catalyzed hydration, base-catalyzed hydration) 2. Which reagent is necessary for step 3? (Br2, HBr, H2/Pt, NaNH2, H20/H2SO4/HgSO4)
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