Rh-negative individuals generate an immune response when they are exposed to the Rh-negative antigen

Human Heredity: Principles and Issues (MindTap Course List)
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ISBN:9781305251052
Author:Michael Cummings
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Chapter17: Genes And The Immune System
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Problem 15QP
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Rh-negative individuals generate an immune response when they are exposed to the Rh-negative antigen. However, incompatibility in the ABO blood group system occurs naturally in the absence of exposure to the A or B antigen in the blood from another individual. Why do individuals produce an immune response the first time they encounter the A or B antigen as an adult?

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