Rh D - negative individuals generate an immune response when are exposed to the Rh -D antigen . However, incompatibility in the ABO blood group system occurs naturally in the absence pf expsure to the A or B antigen in the blood from another individual. Why do individuals produce an immune response the first time encounter the A or B antigen as an adult?

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Chapter17: Genes And The Immune System
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 Rh D - negative individuals generate an immune response when are exposed to the Rh -D antigen . However, incompatibility in the ABO blood group system occurs naturally in the absence pf expsure to the A or B antigen in the blood from another individual. Why do individuals produce an immune response the first time encounter the A or B antigen as an adult?  

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