SBI 3U0 Single Trait Inheritance Activity For this activity, assume that each trait is controlled by a single pair of alleles. Observation Chart Earlobe Attachmen Hand Tongue Rolling Widow Peak Eye Pigment Taster Bent Bent Test Clasping Thumb Finger Phenotyp e Genotype Procedure: Determine your genotype and phenotype for each of the following 8 traits. Record your observations in the chart above. Note: When writing the genotype of a dominant trait, use a capital letter followed by a dash (i.e. B-). When writing the genotype for a recessive trait, use two lower case letters (i.e. bb)
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- Plsssssss helppppppp, should an individual have have children if they know there is a chance they could pass on a trait that could have negative health consequences? Should individuals screen their genes through their health care provider before deciding to have children?Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?
- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?The following table gives the percentage of twinpairs studied in which both twins expressed the same phenotypefor a trait (concordance). Percentages listed arefor concordance for each trait in monozygotic (MZ) anddizygotic (DZ) twins. Assuming that both twins in eachpair were raised together in the same environment, whatdo you conclude about the relative importance of geneticversus environmental factors for each trait?Single gene Mendelian inheritance patterns: if you are told the phenotype of the parents and whether the trait is dominant or recessive etc, be able to predict the genotype of the children. If you are told the phenotype of the parent as well as the inheritance pattern, be able to predict the parent’s genotype. Be able to set up and use a Punnett square to solve problems and make predictions. Be able to explain the major steps in how information from our genes is used to make proteins. Or to show it in a labeled diagram. Be able to explain whatis transcription, translation. Where in the cell do these processes occur? In what order? What type of molecules are being made [DNA, RNA, protein]? What are their building blocks? What is a mutation? How can a mutation in DNA cause a change in a protein? (use the following terms to answer: codon, transcription, translation, mRNA). What is gene expression? Why is regulation of gene expression important for normal…
- six small pedigrees are displayed. Indicate with J (yes) or N (No) if each pedigree is compatible with each of the following types of inheritance. Assume that the genetic characteristics are common in general population. Use table just like the table below in answering A B C D E F Autosomal Recessive Autosomal Dominant X-bound recessive X-bound dominant Y-BottomWhat will thr possible offspring from a dad who is heterozygous for freckles and a mom who is homozygous recessive for the freckles trait? Having freckles is the dominant trait while no freckles is recessive. Include Punnett square, genotypic and phenotypic ratios.Use Punnett Square:The letter that accompanies each trait is representative of the dominant allele. This is the letter you will use when recording the genotypic information for each trait.Read through the descriptions of each trait and determine which phenotype you express. Record your phenotypeNext, determine your genotype. If you express the dominant phenotype, you cannot determine the second allele you carry, so you must list the two possible genotypes. Record this. Question: Eye color (B): Inheritance of eye color is controlled by multiple genes, but people having the homozygous recessive genotype have blue eyes. People who have a dominant allele may have different shades of brown, hazel, or green eyes.
- Use Punnett Square:The letter that accompanies each trait is representative of the dominant allele. This is the letter you will use when recording the genotypic information for each trait.Read through the descriptions of each trait and determine which phenotype you express. Record your phenotypeNext, determine your genotype. If you express the dominant phenotype, you cannot determine the second allele you carry, so you must list the two possible genotypes. Record this. Question: Widow’s Peak (W): A hairline that forms a downward point in the middle of the forehead is caused by a dominant allele. A smooth hairline is caused by a recessive genotype.For a typical complex trait, describe the relationship betweenthe number of genes affecting the trait and the magnitude oftheir effects on the trait.Write down symbols for the alleles. (These may be given in theproblem.) When represented by single letters, the dominantallele is uppercase and the recessive is lowercase.