SN2 reactions takes place with inversion of configuration, while SN1 reaction takes place with racemization. The following substitution reaction however, occurs with complete retention of configuration. Propose a mechanism. CH, CH, но 1. 1% NAOH, H,0 он Br HO 2. Н,о

Q: 2. Show how to accomplish the following transformation: OCH3 NHCH3

A: Hydrolysis of amide followed by esterification leads to the desired product.

Q: Provide a reasonable mechanism for the following transformation. 1. NaNH2 2. CH3I 3. H9SO4,…

A: In organic reaction, a nucleophile attacks an electrophile.

Q: A hydrogen and the leaving group have to be antiperiplanar in which reaction? O E2 O inversion O SN1…

A: The leaving groups and hydrogen leave when from the given organic substrate if the reaction goes…

Q: the product(s) reaction below. cách product reaction mechanism that produced it (SN2/SN1/E1/E2) and…

A: Stereochemistry  only  change in SN2 Reaction  because  of the fact that Backside  attack of…

Q: OH NH2 Неpt + CH3SO,CI + CH3(CH2)NHET H3C (a) (b) (c) (d) (c) SOCI2 (a) + (b) H3PO4 OH Et Неpt (d)…

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Q: Propose a mechanism for the following reaction that explains why the configuration of the asymmetric…

A: SN2 reaction involves the nucleophilic attack from the back side of the carbon atom. As the product…

Q: The products of the given reaction are, E2 CH;CH,Br H,C=CH2

A: In Nitrogen containing Lewis base its lone pair of electron is present in sp2 hybrid orbital ,which…

Q: 1. 98% H2SO4 Ме OMe Br- -78 °C 2. Li e ČO,Me OMe -78 °C-rt, THF

A: Robinson annulation followed by Quasi-favorskii reaction will give the desired product.

Q: Consider the intramolecular nucleophilic substitution reaction shown here. Does the stereochemistry…

A: The given intramolecular nucleophilic substitution reaction is,

Q: Show Steps for Mechanism and Box Final Product D HBr, ROOR La) 2 PP hg 3) Buli 4) (CHg)z C =0 ) Mg,…

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Q: Classify the following reaction as an Sn1, Sn2, E1, E1cB, E2 reaction. Can you show me the leaving…

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Q: Which site on the benzene derivative shown below is the most likely to undergo electrophilic…

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Q: A hydrogen and the leaving group have to be antiperiplanar in which reaction? O SN1 O inversion O…

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Q: 3. Provide the mechanism for the following rxn: ethanol heat Br a. CH3 CH3 NAOCH3, CH3OH Br b. DH H.…

A: Mechanism of Elimination reaction:

Q: What sequence of reagents would best achieve the transformation shown below? NH, O1) Br, FeBr 2) Fe,…

A: Hey, since there are multiple questions posted, we will answer first question. If you want any…

Q: NaN3 Br

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Q: Rxn involve cleavage of -H Na NaOH CH3CH,C-OH Na,CO3 + iii) Reduction i. LİA||1, CH;CH,C– OH ii.…

A: Introduction: Carboxylic acid: Carboxylic acid is an organic acid with general formula RCOOH. R can…

Q: 1. Draw a plausible mechanism for the following transformation. H H2SO4 N° + 2H20 + NH2NH2 H

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Q: An allylic substrate is more favorable for unimolecular E1/Sn1 reactions than a 3° substrate because…

A: Since you have asked multiple questions, we will solve the first question for you. If you want any…

Q: Draw the Mechanism of Ether Cleavage in Strong Acid—(CH3)3COCH3 + HI → (CH3)3CI + CH3I + H2O

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Q: Which reaction sequence would accomplish this transformation? OCH2CH3 HO (A) NaH Å CH;CH,I_ (B)…

A: In order to carry out the given conversion reaction, we have to consider the given options and…

Q: HOE Br

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Q: Supply the required reag ents to carry out the Following transformation in me the correct order. ?…

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Q: For each pair of aromatic compounds, determine which will undergo electrophilic aromatic…

A: Since your question has multiple sub-parts, we will solve first three sub-parts for you. If you want…

Q: Which structure below is the best substrate for an SN2 reaction? A. CH3CH2CH2CH2CH2Br B.…

A: Bimolecular nucleophilic substitution reaction (SN2): The attack of nucleophile (Nu−) with alkyl…

Q: Draw a plausible mechanism for the following transformation. H2SO4 + NH,NH2 + 2H20

A: Since you have asked multiple questions, we will solve the first question for you. If you want any…

Q: 5. Propose a synthetic pathway for molecule X to molecule Y using the reagents boxed below. Note…

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Q: a) Carry out the following transformation and provide mechanism. C,H; CH: H a) H.C. C NH2 -COOH Ph…

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Q: TM H Show the synthetic sequence that converts acetylene to the target molecule (TM) shown below.

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Q: Propose a mechanism for the following reaction that explains why the configuration of the asymmetric…

A: In the above mechanism, the diazonium compound is offensive by electron-rich substrates. The…

Q: The major product of the following reaction is an alcohol. Which of the following best describes…

A: Ans

Q: Please state if the substrate below undergoes a carbocation rearrangement in an SN1 mechanism

A: In SN1  mechanism carbocation rearrangement takes place when that carbocation is not stable and and…

Q: NaOEt CI ELOH

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Q: DBU OTs DMSO Me Ме Me

A: A question based on elimination reaction, which is to be accomplished.

Q: Furfuryl ethyl ether (FEE) was identiied as a component that forms in aged beer, giving ita…

A: Protonated alcoholic group of furfuryl alcohol eliminates water molecule to produce carbocation…

Q: 1- Which compound undergoes substitution by the SN mechanism at the fastest rate? A) ME Br B) Br C)…

A: Reactivity of SN2  reaction :

Q: CH3 HO OCH3 CH3 HO, ČH3 OCH3 H* Ph ACTUAL PRODUCT

A: H+ is catalyst here,it promotes the reaction by increasing the electrophilicity

Q: Can you tell me how to draw all the possible elimination and substitution products? Also can you use…

A: The possible elimination and substitution product can be drawn asThe given substrate is undergoes to…

Q: Sometimes Aidol-type products can be forged in non-canonical ways Provide a mechanism tor the…

A: The explanation is given below-

Q: Draw the detailed mechanisms for the following transformations. H3C =OCH 3 LOCH3 (1.5 equiv) then…

A: We have to draw the detail mechanism for the following given transformations as follows in step 2:

Q: An NH2 group_the ring toward electrophilic aromatic substitution by. a. activates, the inductive…

A: An NH2 group activates the ring toward electrophillic aromatic substitution by resonance. Option "c"…

Q: SN1 reactions undergo carbocation rearrangements, but E1 reactions do not because the carbocation…

A: SN1 reactions undergo carbocation rearrangements, but E1 reactions do not because the carbocation…

Q: Which reaction proceed according to an E2 mechanism? toe. 3D II ethanol heat Br heat Br DMSO towe.…

A: E2 elimination generally occurs in the presence of heat, complete in one step and form alkene. As…

Q: Show the mechanism for the nucleophilic aromatic substitution below. Br NH2 NaNH, ZON NaBr ZON

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Q: Draw both the SN1 and E1 products of each reaction. Br а. H20 b. HO,

A: The SN1 reaction is the unimolecular nucleophilic substitution reaction and E1 reaction is the…

Q: Which mechanism of substitution is most favorable for the compound below? O SN2 O SN1 Br O none of…

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Q: Which of the following ff. halides is most likely to react through the SN1 mechanism? i. CH3Cl ii.…

A: SN1 reaction is passing through the formation of carbocation intermediate. Greater is the stability…

Q: Which site in the molecule below is most reactive in electrophilic aromatic substitution? (а) OH (b)…

A: Answer:- This question is answered by using the simple concept of directive effect of disubstituted…

Q: Draw the detailed mechanisms for the following transformations. H3C 0CH 3 (1.5 equiv) OCH3 then…

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Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.