Please explain Spontaneous oxidative deamination of guanine produces the base xanthine (see figure, which also shows aG-C base pair). If DNA replication occurred before this damage was repaired, what would happen when thereplicative DNA polymerase reached xanthine on the template strand?●●●NHONHxanthineNHNNHguanineAnswer Key: A----- NA. DNA polymerase would probably incorporate C opposite xanthine.ZIcytosneB.DNA polymerase would stall, requiring a translesion DNA polymerase to synthesize DNA past the site ofdamage.C. DNA polymerase would probably incorporate a base other than C opposite xanthine.D. DNA polymerase would change the xanthine back to guanine using its proofreading activity.

As per the Watson-Crick model of the DNA double helix:DNA is made up of two strands of…

Spontaneous oxidative deamination of guanine produces the base xanthine (see figure, which also shows a G-C base pair). If DNA replication occurred before this damage was repaired, what would happen when the replicative DNA polymerase reached xanthine on the template strand? ● N N H N H xanthine NH N N H N H guanine H A. DNA polymerase would probably incorporate C opposite xanthine. ZI cytosne B. DNA polymerase would stall, requiring a translesion DNA polymerase to synthesize DNA past the site of damage. C. DNA polymerase would probably incorporate a base other than C opposite xanthine. D. DNA polymerase would change the xanthine back to guanine using its proofreading activity.

Spontaneous oxidative deamination of guanine produces the base xanthine (see figure, which also shows a G-C base pair). If DNA replication occurred before this damage was repaired, what would happen when the replicative DNA polymerase reached xanthine on the template strand? ● N N H N H xanthine NH N N H N H guanine H A. DNA polymerase would probably incorporate C opposite xanthine. ZI cytosne B. DNA polymerase would stall, requiring a translesion DNA polymerase to synthesize DNA past the site of damage. C. DNA polymerase would probably incorporate a base other than C opposite xanthine. D. DNA polymerase would change the xanthine back to guanine using its proofreading activity.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 18QP: Replication involves a period of time during which DNA is particularly susceptible to the...

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Deamination of adenine results in the formation of hypoxanthine. Hypoxanthine selectively base pairs with cytosine. If this error is not corrected, what base pair can the original A·T base pair be converted to after cycles of DNA replication?a) G·C b) C·G c) T·A d) A·G
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