Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactions (N in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI dipole-dipole hydrogen bond polarizability, size; molecular weight ionic interaction Species able to form that NCI any species with permanent dipoles (C-O, etc.) H bonded to N, O, or F and F a dielectric size; type of charge Parameters affecting the NCI ions; charged species strength and orientation of dipole orientation dispersion

Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactions (N in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI dipole-dipole hydrogen bond polarizability, size; molecular weight ionic interaction Species able to form that NCI any species with permanent dipoles (C-O, etc.) H bonded to N, O, or F and F a dielectric size; type of charge Parameters affecting the NCI ions; charged species strength and orientation of dipole orientation dispersion

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter4: Polar Bonds, Polar Reactions

Section: Chapter Questions

Problem 10CTQ

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