The activity of isocitrate dehydrogenase in E. coli is regulated by the covalent attachment of a phosphate group, which inactivates the enzyme. When acetate is the food source for a culture of E. coli, isocitrate dehydrogenase is phosphorylated. However, when glucose is added to the culture, the phosphate group is removed from isocitrate dehydrogenase. These observations indicate that acetate metabolism proceeds through the citric acid cycle *, while glucose metabolism proceeds through the gluconeogenesis pathway

The activity of isocitrate dehydrogenase in E. coli is regulated by the covalent attachment of a phosphate group, which inactivates the enzyme. When acetate is the food source for a culture of E. coli, isocitrate dehydrogenase is phosphorylated. However, when glucose is added to the culture, the phosphate group is removed from isocitrate dehydrogenase. These observations indicate that acetate metabolism proceeds through the citric acid cycle *, while glucose metabolism proceeds through the gluconeogenesis pathway

Chemistry for Today: General, Organic, and Biochemistry

9th Edition

ISBN:9781305960060

Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen

Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen

Chapter23: Carbohydrate Metabolism

Section: Chapter Questions

Problem 23.66E: Lactate dehydrogenase catalyzes the following equilibrium reaction in both liver and muscle cells:...

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