The following is an intermediate formed during a FAS. The primer shown is condensed with 4 moles of malonyl-COA. How many reduction steps took place (or how many equivalents of NADPH are needed) to make this intermediate? OH lla FAS H3C, COA + 4 CoA H3C, но A 1 В 2 C 3 D 4 E 5 F 6 G 7 H 8
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- succinyl-COA synthetase will do which of the following: Select one: a. Fumarate is combined with water to become Malate b. alpha-ketoglutarate is oxidized and decarboxylated to produce Succinyl-CoA, Carbon dioxide and NADH c. Succinate is oxidized to become fumarate forming FADH2 d. Citrate is rearranged to become Isocitrate e. Malate is oxidized to become oxaloacetate forming NADH f. Pyruvate is decarboxylated to become acetyl-CoA producing NADH and Carbon dioxide g. Succinyl-CoA becomes Succinate and forms one ATP molecule and Coenzyme A-SH h. Oxaloacetate combines with the acetyl from acetyl-CoA to produce Citric acid(citrate) i. Isocitrate and then decarboxylated and oxidized to produce alpha-ketoglutarate, Carbon dioxide and NADHThe complete oxidation of palmitoyl-CoA to carbon dioxide and water is presented by the overall equation: Palmitoyl-CoA + 23O2 + 108Pi + 108 ATP + 23H2O → CoA + 16 CO2 + 108 ATP + 23H2O Water is also produced in the reaction ADP + Pi → ATP + H2O But not included as a product in the overall equation. Why?How many reduced molecules (NADH, FADH2, NADPH) will be generated by converting linoleic acid (18:2Δ9,12) to acetyl-CoA?
- If the w-carbon atom of a fatty acyl CoA molecule with a C18 chain is labeled with C14, how many rounds of β-oxidation are required to produce a radioactively labeled acetyl CoA? a. four b. five c. six d. seven e. eight f. nineAcetly CoA can quickly enter the citric acid cyle by joining with a C4 compound and forming citrate. Meanwhile, GTP (or ATP) is generated using inorganic phosphate while succinyl CoA is converted to succinate. What is the main reason both acetly CoA and succinyl CoA can perform such work? a. Acetyl CoA and succinyl CoA both contain coenzyme A, which is a high-energy compound. b. Acetyl CoA and succinyl CoA both form an unstable thioester bond with coenzyme A. c. Acetyl CoA and succinyl CoA both bind with inorganic phosphate which is used to generate ATP (or GTP). d. Acetyl CoA and succinyl CoA both transiently form a covalent bond with the enzymes that catalyze the next reaction, pyruvate dehydrogenase and succinyl-CoA synthetase, respectively. e. Acetyl CoA and succinyl CoA use the energy collected from the electron transport chain.Which of the following coenzymes does not get restored to it's original form within the PDH complex once pyruvate gets converted to acetyl CoA a. NAD+ b. TPP c. Lipolic Acid d. FAD
- Which of the following intermediates of the TCA cycle has 5 carbons? (Hint: You don't need to have memorized specific structures for this question, just recall what molecules the TCA cycle starts with and where in the cycle carbons are lost as CO2 ). a) Fumarate b) None of the above c) Succinyl CoA d) Citrate e) Oxaloacetatewhat is the metabolic reaction\pathway in which the propionyl CoA caboxylase evzyme is involved ? ( what is the propionayl CoA carboxylase doing\function in the cell)The citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options, please choose more than one. Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4
- Which one of the following will function to inhibit CPT1? A.palmitoyl-CoA B.citrate C propionyl-CoA D.acetyl-CoA E malonyl-CoAWhich of the following is true regarding the oxidation of 1 molecule of palmitate to 8 molecules of acetyl CoA by the beta-oxidation pathway? 7 molecules of FADH2 are formed None of the above 8 molecules of FADH2 are formed 8 molecules of NADH are formed BOTH 8 molecules of NADH are formed AND 8 molecules of FADH2 are formedComplete the following paragraph describing the fate of the second 14CO-acetyl-CoA molecule incorporated into the glyoxylate cycle. The glyoxylate produced in the isocitrate reaction combines with a (A.) 2nd molecule of oxoaloacetate, B.) 2nd molecule of succinate, C.)2nd molecule of acetyl coa) in the malate synthase reaction. Malate is (A.Chiral, B.diasteromeoic C.)Achiral) ; therefore, the oxaloacetate produced from glyoxylate will be labeled at (A.Either of carboxylate carbon B. specifically at methylene carbon C. Specifically at carbonyl carbon D. Specifically at carboxylate carbon bonded to methylene).