Answer a to d for amine reaction Answer ALL parts a) – d).The amine 1 is an anti-cancer drug that is made using the following reaction, whichis catalysed by an imine reductase:ОНСCO2RNADPH.CO2RNH2iminereductase(racemic)1 (99.7% e.e)a) Write a curly-arrow mechanism for this reaction that clearly shows the involvementof NADPH.b) State the maximum yield of this reaction and briefly justify your answer.c) State two problems with using this reaction to obtain amine 1 in multi-gramamounts.d) An engineered ketoreductase can be used to catalyse the following reaction:.CO2ROHC..CO2RНо+ NADP++ NADPH + H+ketoreductase2Propose three advantages of using the ketoreductase and the imine reductase inan enzyme cascade to convert the alcohol 2 into the amine 1.

NADPH is the most favored reducing equivalent used by living organisms in various metabolic…

Answered: The amine 1 is an anti-cancer drug that…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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The amine 1 is an anti-cancer drug that is made using the following reaction, which is catalysed by an imine reductase: OHC. .CO2R .CO2R NADPH NH2 imine reductase (racemic) 1 (99.7% e.e) a) Write a curly-arrow mechanism for this reaction that clearly shows the involvement of NADPH.