The most common method for the synthesis of unsymmetrical ethers is the Williamson synthesis, a reaction (SN2) of an alkoxide ion with an alkyl halide. Two pathways are possible, but often one is preferred. Construct the preferred pathway for the synthesis of 2-propoxypropane from propene, with propene-derived alkyl halide and alkoxide intermediates, by dragging the appropriate intermediates and reagents into their bins. Not every given reagent or intermediate will be used. HBr ROOR Но Br Step 1 Product NaH HBr Reagent 1 CH2CI2 H20 H2SO4 propene B2H6 H2O2 Br Reagent 2 Reagent 3 НО Step 2 Product Step 3 Product Na+ Nat - NaBr 2-propoxypropane
The most common method for the synthesis of unsymmetrical ethers is the Williamson synthesis, a reaction (SN2) of an alkoxide ion with an alkyl halide. Two pathways are possible, but often one is preferred. Construct the preferred pathway for the synthesis of 2-propoxypropane from propene, with propene-derived alkyl halide and alkoxide intermediates, by dragging the appropriate intermediates and reagents into their bins. Not every given reagent or intermediate will be used. HBr ROOR Но Br Step 1 Product NaH HBr Reagent 1 CH2CI2 H20 H2SO4 propene B2H6 H2O2 Br Reagent 2 Reagent 3 НО Step 2 Product Step 3 Product Na+ Nat - NaBr 2-propoxypropane
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter9: Nucleophilic Substitution And Β-elimination
Section: Chapter Questions
Problem 9.48P: The Williamson ether synthesis involves treatment of a haloalkane with a metal alkoxide. Following...
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