The pA value for a drug-receptor pair .. (choose best answer) O indicates concentration at which the drug binds 50% of available receptors. O will depend on what agonist was used in the experiment. O will have a smaller numerical value if the affinity is greater. O will not be affected by changing the drug's molecular structure. O none of these
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- Receptors, such as G-protein coupled receptors (GPCRs) are common drug targets.Ligands that target receptors are often characterised as being agonists orantagonists. Explain, with the aid of figures as appropriate, what these two termsmean.Drugs bind to receptor and give response to the body. What type of binding involve in this process ?Here’s the fractional binding data for 2 different proteins (1 and 2) binding to a Drug D. Which of the following statements is/are true? 1 of 5: Each Protein 1 must only bind 1 molecule of D. 2 of 5: Each Protein 2 must bind 2 or more molecules of D. 3 of 5: Protein 2 binds significantly more D than Protein 1. 4 of 5: Protein 1 and 2 have roughly similar binding affinities for D. 5 of 5: Protein 1 binds faster to D than protein 2 does at low concentrations of D.
- What are some of the forces that control the strength of interaction between a drug and a receptor?How a drug works in the body is called: A. Pharmacodynamics B. Pharmacokinetics C. MOA D. Receptor site E. Both A and CIf drug X has an ED50 of 10 and LD50 of 50. Drug Y has an ED50 of 10 and LD50 of 100. Which of the following statement is correct? A.Drug X is safer than drug Y B.Drug Y is safer than drug X. C.Drug X is more potent than drug Y D.Drug Y is more potent than drug X E.Drug X is less potent than drug Y
- Present the comparison of pharmacokinetics vs pharmacodynamics. Why the identification of different types of receptors is so important for drug’s pharmacodymics?Choose the best term which describe the following statement: antagonist binds to the binding site of receptor and change the shape: Select one: Incorrect Induced fit. Correct induced fit. Signal transduction. Perfect fit.Determine if the following statement regarding the picture are correct. Drug B is a full antagonist. Drug D is relatively safer to use clinically than Drug B and C. Drug A is relatively more potent than Drug B. Drug D is a pharmacological antagonist. All drugs are agonist.
- Explain whether the specificity of interaction will be high or low for each given situation. a. The value of KD of the ligand's interaction to the target receptor is very much lower than the value of KD of the ligand's interaction to off-targets. b. The ligand concentration [L] is higher than the KD value of its interaction with the target and the KD value of its interaction to off-targets.Activity of thionamide is potentiated by all of the following, except:A. AnticoagulantsB. Beta blockersC. SulfasalazineD. ACE inhibitorsE. Theophylline.) How can these physiological factors listed below affect drug effect? Explain each. - diurnal rhythm - acid - base balance - hydration - electrolyte balance।