The peptide aspartyl-glutamyl-leacyl-threony-alanine, shown in the sketch drewing window, has several ionizable proups. Adjust the charges to show the molecule ast would etist at pH 5.00. Use the pk, values in the table below.
The peptide aspartyl-glutamyl-leacyl-threony-alanine, shown in the sketch drewing window, has several ionizable proups. Adjust the charges to show the molecule ast would etist at pH 5.00. Use the pk, values in the table below.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:The peptide aspartyl-glutamyl-leucyl-threonyl-alanine, shown in the sketch drawing window, has several ionizable groups. Adjust the charges to show the molecule as it would exist at pH
5.00. Use the pk values in the table below.
pK, Values for Ionizable Groups of Amino Acids.
Amino Acid pA, of a-COOH pA, of e-NH,
pA, of Side Chain Isoelectric Point (pI)
Alanine
235
9.87
6.11
Arginine
2.01
9.04
12.48
10.76
Asparagine
2.02
8.80
5.41
Aspartic acid
210
9.82
3.86
298
Cysteine
2.05
10.25
8.00
5.02
Glutzmic acid 2.10
9.47
4.07
3.08
Glutamine
217
9.13
5.65
Glycine
235
9.78
6.06
Histidine
7.11
9.18
6.10
7.64
Isoleucine
232
9.76
6.04
Leucine
233
9.74
6.04
Lysine
218
8.95
10.53
9.74
Methionine
2 28
9.21
5.74
Phenylalanine 2 58
9.24
5.91
Proline
2.00
10.60
6.30
Serine
221
9.15
5.68
Threonine
2.09
9.10
5.60
Trуptophan
238
9.39
5.88
Tyrosine
2 20
9.11
10.07
5.63
Valine
2 29
9.72
6.00
• Use the wedge hash bond tools to indicate stereochemistry where it exists.
• If a group is 2chiral, do not use wedged or hashed bonds on it.
Should you want to restart the exercise, the drop-down menu labeled == starting points == can be used to redraw the starting molecule on the sketcher.
apy te
CH
HO
NH,
CH,
CH,
ChemDoodle"
starting points ==
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