The percentage purity of a paracetamol sample was determined by a reversed phase HPLCmethod as follows:• A calibration curve of peak area versus concentration (ug/mL) of pure paracetamolwas constructedThe paracetamol sample for analysis was prepared by taking 10.0254 g of powder anddissolving it in IL of distilled water (solution A). 1 mL of the latter solution wasfurther diluted to 1L with distilled water (solution B). Solution B was analysed byHPLC analysisResults• The equation for the best-fit line of the calibration curve is:y = 26811x – 1313.8The average peak area for the paracetamol sample (solution B) was 266796.2Calculate the percentage purity of the paracetamol powder.

Given: Mass of powder taken = 10.0254 g. Volume of solution A prepared = 1 L Volume of solution A…

The percentage purity of a paracetamol sample was determined by a reversed phase HPLC method as follows: • A calibration curve of peak area versus concentration (ug/mL) of pure paracetamol was constructed • The paracetamol sample for analysis was prepared by taking 10.0254 g of powder and dissolving it in IL of distilled water (solution A). I mL of the latter solution was further diluted to 1L with distilled water (solution B). Solution B was analysed by HPLC analysis Results • The equation for the best-fit line of the calibration curve is: y= 26811x - 1313.8 The average peak area for the paracetamol sample (solution B) was 266796.2 Calculate the percentage purity of the paracetamol powder.

The percentage purity of a paracetamol sample was determined by a reversed phase HPLC method as follows: • A calibration curve of peak area versus concentration (ug/mL) of pure paracetamol was constructed • The paracetamol sample for analysis was prepared by taking 10.0254 g of powder and dissolving it in IL of distilled water (solution A). I mL of the latter solution was further diluted to 1L with distilled water (solution B). Solution B was analysed by HPLC analysis Results • The equation for the best-fit line of the calibration curve is: y= 26811x - 1313.8 The average peak area for the paracetamol sample (solution B) was 266796.2 Calculate the percentage purity of the paracetamol powder.

Fundamentals Of Analytical Chemistry

9th Edition

ISBN:9781285640686

Author:Skoog

Publisher:Skoog

Chapter31: Introduction To Analytical Separations

Section: Chapter Questions

Problem 31.19QAP

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